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  4. Recombinant Rat ADP-ribosyl cyclase 1 (Cd38), partial

Recombinant Rat ADP-ribosyl cyclase 1 (Cd38), partial

  • 货号：
    CSB-YP731039RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP731039RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP731039RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP731039RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP731039RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; EC 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; EC 2.4.99.20; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; CD38H; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD antigen CD38
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity.; Regulates osteoclastic bone resorption, probably via production of cyclic ADP-ribose and triggering of a cytosolic calcium ion signal through ryanodine receptor activation.
  • 基因功能参考文献：
    1. CD38 plays an essential role in cardiac hypertrophy probably via inhibition of SIRT3 expression and activation of Ca(2+) -NFAT signaling pathway. PMID: 28296029
    2. Study found that deletion of CD38 caused impaired astrocytic and oligodendrocytic development in the cortex, probably by increasing NAD+ levels and decreasing Cx43 expression levels. PMID: 28295574
    3. CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway. PMID: 27547294
    4. CD38 activation after NADPH depletion triggers endothelial dysfunction in the postischemic heart PMID: 26297248
    5. The mRNA level of CD38 in intermittent hypoxia -treated islets was significantly lower than that in normoxia-treated islets. PMID: 22154909
    6. observed the preferential localization of CD38 in the basolateral plasma membrane and intracellular granule-like membrane in sublingual acinar cells under resting conditions PMID: 21784055
    7. The ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells PMID: 20870729
    8. first report of a functionally active ADP-ribosyl cyclase/CD38 in the spleen nuclear fraction PMID: 11733184
    9. role in synthesis of nicotinic acid-adenine dinucleotide phosphate in mammalian tissues PMID: 11829748
    10. membrane-bound CD38 is present in pancreatic acinar cells PMID: 12807891
    11. CD38 can act as a regulator of hepatic stellate cells activation and effector functions PMID: 17200192
    12. ADP-ribosyl cyclase and ryanodine receptors participate in L-type channel-mediated renal vasoconstriction in vivo. PMID: 17652368
    13. Activation of ADPR-cyclase by ANG II entails a novel signaling pathway involving sequential activation of Src, PI 3-kinase/Akt, and PLC-gamma1/IP(3) and that the activation of ADPR-cyclase can lead to cardiac hypertrophy. PMID: 18456728
    14. In the renal microcirculation in vivo, ET-1-induced vasoconstriction is mediated by ADP-ribosyl cyclase and ryanodine receptors, and ETA and ETB receptors activate this pathway. PMID: 18524860
    15. Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. PMID: 18719074
    16. Data show that perinatal brain injury led to a significant increase in enzyme expression during the first 3 days after brain hypoxia/ischemia. PMID: 19513369
    17. CD38/cADPR/Ca2+ pathway promotes cell proliferation and delays nerve growth factor-induced differentiation in PC12 cells. PMID: 19696022

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  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    ADP-ribosyl cyclase family
  • 组织特异性：
    Spleen, liver, heart, thymus, thyroid gland, ileum, colon, cerebellum, salivary gland, adrenal gland, jejunum, islets of Langerhans and osteoclasts.
  • 数据库链接：

    KEGG: rno:25668

    STRING: 10116.ENSRNOP00000004121

    UniGene: Rn.11414