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  4. Recombinant Rabbit ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), partial

Recombinant Rabbit ATP-sensitive inward rectifier potassium channel 11 (KCNJ11), partial

  • 中文名称：
    小圆锥花果KCNJ11重组蛋白
  • 货号：
    CSB-YP012049RB1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小圆锥花果KCNJ11重组蛋白
  • 货号：
    CSB-EP012049RB1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小圆锥花果KCNJ11重组蛋白
  • 货号：
    CSB-EP012049RB1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小圆锥花果KCNJ11重组蛋白
  • 货号：
    CSB-BP012049RB1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小圆锥花果KCNJ11重组蛋白
  • 货号：
    CSB-MP012049RB1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    KCNJ11
  • Uniprot No.：
  • 别名：
    KCNJ11; KIR62; ATP-sensitive inward rectifier potassium channel 11; Inward rectifier K(+ channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11
  • 种属：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
  • 基因功能参考文献：
    1. Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 and SUR2B subtypes are reduced in left ventricular hypertrophy models. PMID: 22572849
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ11 subfamily
  • 数据库链接：

    KEGG: ocu:100008648

    UniGene: Ocu.2130