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  4. Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit

Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit

  • 中文名称：
    Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit,Yeast
  • 货号：
    CSB-YP316321PPG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit,Yeast
  • 货号：
    CSB-EP316321PPG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit,Yeast
  • 货号：
    CSB-EP316321PPG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit,Yeast
  • 货号：
    CSB-BP316321PPG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Pomacea canaliculata Perivitellin-2 31 kDa subunit,Yeast
  • 货号：
    CSB-MP316321PPG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Perivitellin-2 31 kDa subunit; PcPV2 31 kDa subunit; PcPV2-31; PV2 tachylectin subunit
  • 种属：
    Pomacea canaliculata (Golden apple snail)
  • 蛋白长度：
    full length protein
  • 表达区域：
    31-286
  • 氨基酸序列
    FTSVKLPRDE HWPYNYVSIG PAGVWAVNRQ NKLFYRTGTY GDNANMGSGW QFKQDGVGQV DVGKDKVGYI NLSGGSLFRI DGISQGNPVG GSPKSWEWWT KYIGMSLRED TRFSSRIENQ NKVLTFTFRT CFWASRITNW CFADSSYTET VTAGGSGTWI TKSQLKYKSG TFGNPDTEGG DWITVDSGSF QHVSSGSGVV LAVRSNGELV KRTGITCSLP QGSGWTSMLN GMSRVDTYGT VAWAVDTYGD LYFINL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The egg defensive protein perivitellin-2 is a pore-forming two-subunit glycoprotein that affects both the nervous and digestive systems of mammals. In addition, it is a source of both structural and energetic molecules during embryonic development (Probable). The tachylectin subunit (31 kDa) binds target membranes while the MACPF subunit (67 kDa) disrupts lipid bilayers forming large pores altering the plasma membrance conductance. Both in vivo and in vitro, the protein shows wide pH range stability and is resistant to enzymatic proteolysis from gastrointestinal environments. It specifically binds mature enterocytes but does not cause cell disruption on caco-2 (human colorectal adenocarcinoma cells) or rat intestinal cells. After oral administration to mice, it binds enterocytes and induces large dose-dependent morphological changes on their small intestine mucosa, reducing the absorptive surface. Additionally, it is detected in the Peyer's patches where it activates lymphoid follicles and triggers apoptosis. The toxin can also traverse the intestinal barrier and induce oral adaptive immunity with evidence of circulating antibody response. The toxin also shows hemagglutination properties thanks to the tachylectin subunit, but does not show hemolytic activity. In addition to enterotoxin activity, the toxin also acts as a neurotoxin, since an intraperitoneal injection induces paralysis of the mice rear limbs, followed by death.
  • 亚细胞定位：
    Secreted. Target cell membrane.
  • 组织特异性：
    Produced by albumen secretory cells. Found in developing eggs.