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  4. Recombinant Plasmodium vivax Putative chloroquine resistance transporter (CG10), partial

Recombinant Plasmodium vivax Putative chloroquine resistance transporter (CG10), partial

  • 中文名称：
    Recombinant Plasmodium vivax Putative chloroquine resistance transporter(CG10),partial,Yeast
  • 货号：
    CSB-YP880915EWW
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Plasmodium vivax Putative chloroquine resistance transporter(CG10),partial,Yeast
  • 货号：
    CSB-EP880915EWW
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Plasmodium vivax Putative chloroquine resistance transporter(CG10),partial,Yeast
  • 货号：
    CSB-EP880915EWW-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Plasmodium vivax Putative chloroquine resistance transporter(CG10),partial,Yeast
  • 货号：
    CSB-BP880915EWW
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Plasmodium vivax Putative chloroquine resistance transporter(CG10),partial,Yeast
  • 货号：
    CSB-MP880915EWW
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CG10
  • Uniprot No.：
  • 别名：
    CG10; CRT-O; PVX_087980Putative chloroquine resistance transporter; Probable transporter cg10; pvcg10; pfcrt ortholog; pvcrt-o
  • 种属：
    Plasmodium vivax (strain Salvador I)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May regulate endogenous transporter.
  • 基因功能参考文献：
    1. Data suggest that mutations in CRT contribute to Plasmodium vivax chloroquine/antimalarial drug resistance; these studies involved quantitative analysis of drug transport mediated by all known mutant isoforms of Plasmodium vivax CRT; elevated transport of chloroquine by specific CRT mutant isoforms is a possible explanation for chloroquine/antimalarial drug resistance in some P. vivax isolates. PMID: 28898049
    2. Expression of Plasmodium vivax crt-o is related to parasite stage but not ex vivo chloroquine susceptibility. PMID: 26525783
    3. chloroquine resistance and clinical severity in P. vivax infections are strongly associated with increased expression levels of the pvcrt-o and pvmdr-1 genes likely involved in chloroquine resistance. PMID: 25157811
    4. A basis is given for the lack of correspondence between P. vivax CRT mutations and resistance to chloroquine in the important malarial parasite P. vivax, compared to P. falciparum CRT. PMID: 21744797
  • 亚细胞定位：
    Vacuole membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CRT-like transporter family
  • 数据库链接：

    KEGG: pvx:PVX_087980

    STRING: 5855.PVX_087980