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  4. Recombinant Pig Type III iodothyronine deiodinase (DIO3), partial

Recombinant Pig Type III iodothyronine deiodinase (DIO3), partial

  • 中文名称：
    野猪DIO3重组蛋白
  • 货号：
    CSB-YP761389PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    野猪DIO3重组蛋白
  • 货号：
    CSB-EP761389PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    野猪DIO3重组蛋白
  • 货号：
    CSB-EP761389PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    野猪DIO3重组蛋白
  • 货号：
    CSB-BP761389PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    野猪DIO3重组蛋白
  • 货号：
    CSB-MP761389PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DIO3
  • Uniprot No.：
  • 别名：
    DIO3; Thyroxine 5-deiodinase; EC 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
  • 基因功能参考文献：
    1. The imprinted gene DIO3 is a candidate gene for litter size in pigs PMID: 22393372
    2. DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits. PMID: 21660470
    3. expression of D3 was observed in cerebrum and was positively regulated by thyroid state. PMID: 15192045
  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Iodothyronine deiodinase family
  • 组织特异性：
    Expressed in brain only.
  • 数据库链接：

    KEGG: ssc:414378

    STRING: 9823.ENSSSCP00000002752

    UniGene: Ssc.26332