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  4. Recombinant Pig Haptoglobin (HP)

Recombinant Pig Haptoglobin (HP)

  • 货号：
    CSB-YP010691PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010691PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010691PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010691PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010691PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    HP; Haptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-347
  • 氨基酸序列
    AE TGNEATDATD DSCPKPPEIP KGYVEHMVRY HCQTYYKLRT AGDGVYTLDS NKQWTNKVTG EKLPECEAVC GKPKNPVDQV QRIMGGSLDA KGSFPWQAKM ISHHNLTSGA TLINEQWLLT TAKNLRLGHK NDTKAKDIAP TLRLYVGKKQ EVEIEKVIFH PDNSTVDIGL IKLKQKVPVN ERVMPICLPS KDYVNVGLVG YVSGWGRNAN LNFTEHLKYV MLPVADQEKC VQYYEGSTVP EKKTPKSPVG VQPILNEHTF CAGLSKYQED TCYGDAGSAF AVHDKDDDTW YAAGILSFDK SCRTAEYGVY VRVTSILDWI QTTIADN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  • 基因功能参考文献：
    1. crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution PMID: 22922649
    2. This protein is elevated in porcine postweaning multisystemic wasting syndrome. PMID: 15210076
    3. haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress PMID: 16438801
    4. This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin. PMID: 17629575
    5. The haptoglobin was down-regulated with SNPs PMID: 18777092
    6. Presence of haptoglobin alpha 1S subunit is a reponse to respiratory syndrome virus infection. PMID: 18931071

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family
  • 组织特异性：
    Expressed by the liver and secreted in plasma.
  • 数据库链接：

    KEGG: ssc:397061

    STRING: 9823.ENSSSCP00000002967

    UniGene: Ssc.37