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  4. Recombinant Mus musculus Keratinocyte proline-rich protein

Recombinant Mus musculus Keratinocyte proline-rich protein

  • 货号：
    CSB-YP012941MO(I)
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP012941MO(I)
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP012941MO(I)-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP012941MO(I)
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP012941MO(I)
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85%(SDS-PAGE)
  • 基因名：
    Lilrb3
  • Uniprot No.：
  • 别名：
    Lilrb3; Pirb; Leukocyte immunoglobulin-like receptor subfamily B member 3; LIR-3; Leukocyte immunoglobulin-like receptor 3; Cell-surface glycoprotein p91; Paired immunoglobulin-like receptor B; PIR-B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    partial
  • 表达区域：
    664-841aa
  • 氨基酸序列
    RRRHRGKFRKDVQKEKDLQLSSGAEEPITRKGELQKRPNPAAATQEESLYASVEDMQTEDGVELNSWTPPEEDPQGETYAQVKPSRLRKAGHVSPSVMSREQLNTEYEQAEEGQGANNQAAESGESQDVTYAQLCSRTLRQGAAASPLSQAGEAPEEPSVYATLAAARPEAVPKDMEQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
  • 基因功能参考文献：
    1. Loss of gp91 is associated with Bone resorption. PMID: 27897222
    2. Results imply a neuron-specific, cell-autonomous action of PirB on synaptic density in L2/3 pyramidal cells of visual cortex; suggest that PirB is needed to match spine density and excitatory synaptic function to activity levels within cortical circuits, thereby providing headroom for the cell to encode additional experiences at new synapses. PMID: 27752542
    3. peripheral CD4+ T cells from spontaneous murine arthritis model frequently express PIR-B PMID: 28664612
    4. These results provide evidence for a critical role of the major histocompatibility complex class I/PirB signaling system in the generation of asymmetries in hippocampal circuitry. PMID: 28594961
    5. These data identify paired Ig-like receptor B as a molecular checkpoint in IL-13-induced eosinophil accumulation and activation PMID: 27324131
    6. the overexpression of PirB inhibits the neuronal survival through increased neuron apoptosis PMID: 27443384
    7. neural plasticity in adult visual cortex is actively repressed and can be enhanced by blocking PirB function. PMID: 25320232
    8. The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. PMID: 24278366
    9. PIRB and LILRB2 were expressed in mouse and human platelets, respectively. PMID: 25075127
    10. NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where neural stem cells reside. PMID: 24449409
    11. PirB expression is up-regulated after transient focal cerebral ischaemia. It may play pathologic roles in the inhibition of axonal regeneration after stroke. PMID: 23927735
    12. PirB normally regulates spine and excitatory synapse density and consequently the threshold for new learning throughout life. PMID: 24302763
    13. In mice, the deleterious effect of Abeta oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of Alzheimer's disease, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cortex. PMID: 24052308
    14. a key role for PIR-B in IPF, likely via the regulation of macrophage activation PMID: 23258232
    15. study indicates an unexpected functional significance of classical immune-inhibitory receptors in maintenance of stemness of normal adult stem cells and in support of cancer development PMID: 22660330
    16. findings, coupled with previous studies, may imply that PirB is probably a critical molecule in inhibition of axonal regeneration by myelin inhibitors after ON injury PMID: 22102155
    17. This study demonistrated that significant neuroprotection in the absence of the innate immune receptor PirB in mice model of stroke. PMID: 22445338
    18. the p75 receptor is required for the signal transduction of PIR- PMID: 21881600
    19. the major promoter of Pirb, and probably Pira as well, is activated dominantly by PU.1 and marginally by Runx3 in B cells. PMID: 21555536
    20. a novel mechanism by which PIR-B-mediated regulation is achieved differentially but competitively via MHCI and Nogo in cells of the immune system PMID: 21636572
    21. Thus, PIR-B associated with Trk to downregulate basal and neurotrophin-regulated Trk activity through SHP-1/2 in neurons. PMID: 21364532
    22. myeloid-derived suppressor cells genetically ablated for PIR-B underwent a specific transition to M1-like cells when entering the periphery from bone marrow, resulting in decreased suppressive function, regulatory T cell activation activity. PMID: 21376641
    23. PIR-B is an important regulator of innate immunity mediated by TLR9 in B-1 cells, which can otherwise provoke autoimmunity when overactivated (Review) PMID: 20976309
    24. PIR-B knock-out is not sufficient to induce extensive axonal regeneration after spinal cord injury. PMID: 21087927
    25. PirB and Nogo receptor-1 participate in ligand-dependent inhibition of synaptic plasticity in hippocampal slice cultures of adult mice. PMID: 20844138
    26. Blocking the function of PirB is not sufficient to promote axonal reorganization or functional recovery after motor cortex injury. PMID: 20881122
    27. PIR-B negatively regulates macrophage functions in response to pathogenic bacteria and chronic intestinal inflammatory responses. PMID: 20398663
    28. PIR-B is critical for B cell suppression, DC maturation and for balancing T(H)1 and T(H)2 immune responses. PMID: 12021780
    29. HLA-G inhibits the functions of murine dendritic cells via the PIR-B immune inhibitory receptor. PMID: 12207326
    30. Mast cell regulation via paired immunoglobulin-like receptor PIR-B. Review. PMID: 12403357
    31. PIR-B plays a role in regulating signal strength in adhesion-mediated activation of myeloid cells. PMID: 15494528
    32. Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR- PMID: 15723811
    33. PirB, a major histocompatibility complex class I (MHCI) receptor, is expressed in central nervous system neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life PMID: 16917027
    34. We identify murine-paired Ig-like receptor (PIR)-B, and its human orthologs Ig-like transcript 2 and Ig-like transcript 5 as novel receptors for Staphylococcus aureus. PMID: 17371981
    35. constitutive cis binding between LILRB2 or PIR-B and major histocompatibility complex class I has an essential role in regulating allergic responses PMID: 17420263
    36. These findings indicate that sialylated O-linked sugar structures on CD99 play an important role in the recognition of PILR. PMID: 18209065
    37. a single receptor can have dual functionality in distinct cell types after unique cellular signals PMID: 18316626
    38. paired Ig-like receptor (PIR)-B, an MHC-I receptor expressed on antigen-presenting cells, can regulate CTL triggering by blocking the access of CD8 molecules to MHC-I PMID: 18787130
    39. Deletion of PIR-B does not significantly alter either osteoclast or osteoblast function in vivo, at least up to 6 mo of age. PIR-B-deficient mice are not osteoporotic. PMID: 18802077
    40. study found PirB, which has been implicated in nervous system plasticity, is a high-affinity receptor for Nogo, MAG, and OMgp; results implicate PirB in mediating axonal regeneration block PMID: 18988857
    41. T cell expression of PIR-B with the cis-interacting MHC class I is strictly prohibited in periphery so as to secure prompt immune responses. PMID: 19684158
    42. PIR-B on relatively primitive B cells, B-1 cells, suppresses TLR9 signaling via Bruton's tyrosine kinase (Btk) dephosphorylation, blocking the production of natural IgM antibodies. PMID: 19687229

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells.
  • 数据库链接：

    KEGG: mmu:18733

    STRING: 10090.ENSMUSP00000077546

    UniGene: Mm.326531