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  4. Recombinant Mouse fMet-Leu-Phe receptor (Fpr1), partial

Recombinant Mouse fMet-Leu-Phe receptor (Fpr1), partial

In Stock
  • 货号：
    CSB-EP008854MO1
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fpr1; fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    33.7 kDa
  • 表达区域：
    1-35aa
  • 氨基酸序列
    MDTNMSLLMNKSAVNLMNVSGSTQSVSAGYIVLDV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release.
  • 基因功能参考文献：
    1. FPR1-deficient mice showed a slight but significant decrease of demyelination in the corpus callosum and reduced glial cell activation. PMID: 28466255
    2. the FPR1 downstream signaling pathways were competitively inhibited by HCH6-1. Furthermore, HCH6-1 prevented pulmonary neutrophil infiltration and edema along with alveolar damage in LPS-induced ALI in mice. Our findings suggest that HCH6-1, a FPR1 antagonist, may have potential as a new therapeutic agent for treating FPR1-involved inflammatory lung diseases PMID: 28232203
    3. Intravital TPLSM revealed that formyl-peptide-FPR1 signaling is responsible for regulating neutrophil chemotaxis to allow migration into the necrotic area in hepatic ischemia-reperfusion injury PMID: 28062700
    4. Formylated MHC class Ib binding peptides activate both human and mouse neutrophils primarily through FPR1. PMID: 27907124
    5. Blocking of FPR1 completely abrogated the fMet-Leu-Phe-, gliadin- and synthetic peptide-induced migration. PMID: 26378785
    6. these results highlight the importance of FPR1 in chemotherapy-induced anticancer immune responses. PMID: 26516201
    7. Ovalbumininduced airway inflammation is mediated by upregulation of the TLR2/MyD88/NFkappaB signaling pathway and inhibition of LXA4R. PMID: 25760938
    8. Deficiency of formyl peptide receptor 1 is associated with increased inflammation and enhanced liver injury after LPS-stimulation PMID: 24956481
    9. these findings identify a novel role of FPR1 as pattern recognition receptors for perceiving the enteric microbiota that promotes repair of mucosal wounds via generation of reactive oxygen species from the enterocyte NOX1. PMID: 24192910
    10. Further, these results reveal Fpr1 as a major mediator of host commensal interaction during dysbiosis. PMID: 24034617
    11. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 being sole receptor for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. PMID: 23139859
    12. findings may have clinical significance because current smokers and subjects with emphysema showed increased FPR expression in bronchoalveolar fluids and on peripheral neutrophils PMID: 22461430
    13. Neutrophil migration into the inflamed mouse colon does not depend on FPR1, but FPR1 contributes in other pathological mechanisms that are harmful during acute inflammation but are protective during chronic inflammation. PMID: 22383080
    14. Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3 PMID: 21921027
    15. Fpr1 has a role in modulation of anxiety-like behavior and fear memory by regulating glucocorticoid production PMID: 21484271
    16. The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils. PMID: 12470609
    17. Leukocyte antiadhesive and anti-inflammatory actions of annexin 1 involve this receptor. PMID: 12560218
    18. a novel TLR4-linked signaling pathway that selectively couples to the stabilization of FPR1 mRNA. PMID: 17277163
    19. The mechanisms through which these two small GTPases Rac1 and Rac2 mediate free barbed ends generation downstream of the formyl-methionyl-leucyl-phenylalanine receptor, was investigated. PMID: 17954607
    20. study found that mFPR1 is responsible for the high potency of fMIVIL and fMIFL; the ability of mFPR1 to detect bacterially derived formyl peptides indicates that this important host defense mechanism is conserved in mice PMID: 18606697

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.
  • 数据库链接：

    KEGG: mmu:14293

    STRING: 10090.ENSMUSP00000052894

    UniGene: Mm.56951