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  4. Recombinant Mouse Zinc finger and BTB domain-containing protein 32 (Zbtb32)

Recombinant Mouse Zinc finger and BTB domain-containing protein 32 (Zbtb32)

  • 中文名称：
    小鼠Zbtb32重组蛋白
  • 货号：
    CSB-YP864352MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Zbtb32重组蛋白
  • 货号：
    CSB-EP864352MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Zbtb32重组蛋白
  • 货号：
    CSB-EP864352MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Zbtb32重组蛋白
  • 货号：
    CSB-BP864352MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Zbtb32重组蛋白
  • 货号：
    CSB-MP864352MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zbtb32
  • Uniprot No.：
  • 别名：
    Zbtb32; Rog; TzfpZinc finger and BTB domain-containing protein 32; Repressor of GATA; Testis zinc finger protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-465
  • 氨基酸序列
    MPQTPTRLVS PYGSDRLVQL AARLRPALCD TLITVGGLEF PAHSLVLAGA SPRLGCRGRW ALVEDISPST FAQILTFVYG ESIELQPGEL GDLEEAAKAL GVQALEEACQ RAQKGKDEDE LDPGLKRHQQ SEDFMRGSER GLGSPGEKQK PEKDFRSNGR EQEMSHKHKA PGERPEMAGA TRMMSSEEVM RGIESHKGSE ESLRGCPDPL SPPGSLLTSL IPRPWWAEVP RLGEGQSALW SILLWPSRYG APFSHSTPIT AAWQVRPQDQ RIPLTLNHSK ALWSQNQLAS SSPTPGSFPQ GTESLSPWQI ETSGQGFTGT LATCVSQERT LNCPSHQHPP LPSPARSRPY SCSVCGKRFS LKHQMETHYR VHTGEKPFSC SLCPQRSRDF SAMTKHLRTH GAAPYRCPLC RAGCPSLASM QAHMRGHSPS RLPPGWTIRS TFLYSSSRPT RASSSPGSPT SSAAT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells.
  • 基因功能参考文献：
    1. These findings demonstrate that ZBTB32 is a key transcription factor in CD8+ effector T cells that is required for the balanced regulation of effector versus memory responses to infection. PMID: 28827827
    2. ZBTB32 is a novel negative regulator of antibody recall responses. PMID: 27357154
    3. This study showed that DCIR2(+) DCs are capable of inducing antigen-specific tolerance in the face of ongoing autoimmunity; Zbtb32 is a suppressive transcription factor that controls T cell-mediated autoimmunity. PMID: 26070317
    4. Zbtb32 acts as a cellular 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells, thereby allowing their prolific expansion in response to viral infection. PMID: 24747678
    5. that Tzfp function as a transcriptional regulator and that loss of the protein leads to alterations in AR signaling PMID: 23634227
    6. The study reports a remarkable >1000-fold upregulation of individual piRNAs in pachytene spermatocytes isolated from Tzfp-deficient murine testes. PMID: 22965116
    7. It is concluded that ROG can inhibit the expression of Th1 and Th2 cytokines by down-regulating the expression of ICOS, which might be a potential molecular target for asthma treatment. PMID: 22884151
    8. Rog plays an inhibitory role in allergic inflammation. PMID: 21398189
    9. structure of zinc-finger domains; kinetics of DNA binding; DNA sequence-specific binding & nonsequence-specific binding occur simultaneously PMID: 20544958
    10. ROG may confer CD8 T cell-specific repression of histone hyperacetylation and activation of the IL-4 gene locus. PMID: 12932361
    11. ROG is a critical part of a transcription factor NF-ATc2-initiated negative feedback mechanism of T cell activation. PMID: 14688323
    12. PLZP in mice has roles in T-lymphocyte proliferation, cytokine production, and hematopoietic stem cell homeostasis PMID: 15542853
    13. Data show that ROG-deficient T cells are hypersensitive to anti-CD3 stimulation and produce more interleukin-2 (IL-2) due to enhanced NF-kappaB activity. PMID: 15632058
    14. results indicate that ROG regulates allergic airway inflammation and airway hyperresponsiveness in a negative manner PMID: 18620745

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Isoform 1 is testis-specific and is not expressed in lymphoid organs such as thymus or spleen. Isoform 2 is expressed in both B- and T-lymphoid cells.
  • 数据库链接：

    KEGG: mmu:58206

    STRING: 10090.ENSMUSP00000103786

    UniGene: Mm.116789