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  4. Recombinant Mouse Zinc finger and BTB domain-containing protein 17 (Zbtb17)

Recombinant Mouse Zinc finger and BTB domain-containing protein 17 (Zbtb17)

  • 货号：
    CSB-YP736751MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736751MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736751MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736751MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736751MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Zbtb17; Zfp100; Znf151; Zinc finger and BTB domain-containing protein 17; LP-1; Polyomavirus late initiator promoter-binding protein; Zinc finger protein 100; Zfp-100; Zinc finger protein 151; Zinc finger protein Z13
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-794
  • 氨基酸序列
    MDFPQHSQRV LEQLNQQRQL GLLCDCTFVV DGVDFKAHKA VLAACSEYFK MLFVDQKDVV HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVASFLQ MQDIVTACHT LKSLAEPSST TGESADASAV EGGDKRAKDE KAAATMLSRL DQARGSSSTG PGRELKEERG GQAESASSGA EQTEKADAPR EPPPVELKPD PTSSMAAAEA EALSESSEQE MEVEPASKGE DGQEEEGAGP ATVKEEGMHL DNGEPPEENE ESAGTDSGQE LGMEGQNLRS GTYGDRTESK AYGSIIHKCE DCGKEFTHTG NFKRHIRIHT GEKPFSCREC SKAFSDPAAC KAHEKTHSPL KPYGCEECGK SYRLISLLNL HKKRHSGEAR YRCGDCGKLF TTSGNLKRHQ LVHSGQKPYQ CDYCGRSFSD PTSKMRHLET HDTDKEHKCP HCDKKFNQVG NLKAHLKIHI ADGPLKCREC GKQFTTSGNL KRHLRIHSGE KPYVCTHCQR QFADPGALQR HVRIHTGEKP CQCVICGKAF TQASSLIAHV RQHTGEKPYV CERCGKRFVQ SSQLANHIRH HDNIRPHKCS VCSKAFVNVG DLSKHIIIHT GEKPYLCDKC GRGFNRVDNL RSHVKTVHQG KAGIKILEPE EGGEVSVVTV DDMVTLATEA LAATAVTQLT VVPVGAAVTA DETEVLKAEI SKAVKQVQEE DPNTHILYAC DSCGDKFLDA NSLAQHVRIH TAQALVMFQT DADFYQQYGP GSTWPAGQML QAGELVFRPR DGTEGQPTLA ESPPTAPDCL PPAE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49.
  • 基因功能参考文献：
    1. rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1, to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context. PMID: 27926868
    2. the Myc/Miz1 interaction is a defining hallmark of Sonic Hedgehog medulloblastomas development PMID: 26766587
    3. Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination. PMID: 25468973
    4. Miz1 plays an essential role in myelin homeostasis of peripheral nerves. PMID: 25416780
    5. The interaction of Nac1 with Miz1 may thus be relevant to its mechanism of tumourigenesis in ovarian cancer. PMID: 24702277
    6. Conditional knockout of the Miz1 POZ domain in luminal cells during pregnancy caused a lactation defect with a transient reduction of glandular tissue, reduced proliferation and attenuated differentiation. PMID: 24586582
    7. Miz1 may link cell growth and ribosome biogenesis to the transcriptional regulation of vesicular transport and autophagy. PMID: 24088869
    8. Miz1 as a novel regulator in the Hedgehog protein signal pathway that plays an important role in mediating Smo-dependent oncogenic signaling. PMID: 23671675
    9. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc/Miz1 complexes that mediates p21 and p15 down-regulation PMID: 23699408
    10. this study reports that the transcription factor Miz1 was required for terminating lipopolysaccharide (LPS)-induced inflammation. PMID: 23525087
    11. Our data demonstrate that Miz1-mediated attenuation of cell cycle arrest pathways via repression of cdkn1a has a critical role during tumorigenesis in the skin. PMID: 22509363
    12. The repression of TNF-alpha-induced JNK activation by Miz1 is de-repressed by its own site-specific ubiquitination and degradation. PMID: 22184250
    13. We propose that Miz-1 is a critical factor for the pre-T cell beta-selection checkpoint PMID: 21841135
    14. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. PMID: 21258009
    15. Myc represses C/EBPdelta expression by associating with the C/EBPdelta proximal promoter as a transient component of a repressive complex that includes Max and Miz1 PMID: 20426839
    16. Binding of Myc to Miz1 is continuously required to repress CKI expression and inhibit accumulation of trimethylated histone H3 at Lys 9 (H3K9triMe), a hallmark of cellular senescence, in T-cell lymphomas PMID: 20551174
    17. The gene encoding Zfp100 has been assigned to murine chromosome 4 band D3/E1. PMID: 12861998
    18. Our data show that Miz1 is involved in controlling proliferation and differentiation in hair follicles and in hair fiber morphogenesis. PMID: 17635993

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Found in all the embryonic and adult tissues examined.
  • 数据库链接：

    KEGG: mmu:22642

    STRING: 10090.ENSMUSP00000006377

    UniGene: Mm.389590