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  4. Recombinant Mouse Wnt inhibitory factor 1 (Wif1)

Recombinant Mouse Wnt inhibitory factor 1 (Wif1)

  • 货号：
    CSB-YP026113MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP026113MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP026113MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP026113MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP026113MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Wif1; Wnt inhibitory factor 1; WIF-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-379
  • 氨基酸序列
    GQ PPEESLYLWI DAHQARVLIG FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF EVNVIVMNSE GNTILRTPQN AIFFKTCQQA ECPGGCRNGG FCNERRVCEC PDGFYGPHCE KALCIPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC FNGGTCFYPG KCICPPGLEG EQCELSKCPQ PCRNGGKCIG KSKCKCPKGY QGDLCSKPVC EPGCGAHGTC HEPNKCQCRE GWHGRHCNKR YGASLMHAPR PAGAGLERHT PSLKKAEDRR DPPESNYIW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
  • 基因功能参考文献：
    1. Wif1 localizes to the enamel knot in which Wif1 regulates apoptosis by mediating and regulating Wnt-beta-catenin signaling. Thus, Wif1 plays an essential role in tooth development. PMID: 25893927
    2. WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin PMID: 25918249
    3. results demonstrate that Wif1 is not targeted for silencing by DNA methylation in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation PMID: 25571841
    4. EZH2-induced downregulation of WIF1 expression may partially regulate Wnt/beta-catenin-dependent crypt hyperplasia in response to citrobacter rodentium infection PMID: 25486432
    5. Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis. PMID: 24632949
    6. It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases PMID: 23921644
    7. WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males PMID: 24362065
    8. These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism. PMID: 23784913
    9. Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development PMID: 23087175
    10. Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential. PMID: 21652676
    11. wif1 is a modulator of cardiomyocyte differentiation PMID: 21179454
    12. a novel regulatory loop of Bmp4-Smad1-Wif1-Wnt/beta-catenin in coordinating BMP and Wnt pathways to control fetal lung development PMID: 21270055
    13. WIF-1 protein inhibits rod production, and anti-WIF-1 antibodies increase rod production; in contrast, Wnt4 promotes rod production. PMID: 15555925
    14. Dkk-1/Wnt/beta-catenin cascade may mediate the proliferation and migration of hepatocellular carcinoma cells during the metastasis process. PMID: 17964517
    15. Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. PMID: 18586116
    16. Data provided a full expression pattern for Wif1 in limb development, for which no limb expression had been documented so far. PMID: 19185060
    17. Results indicate that WIF-1 plays as a negative regulator of osteoblastic differentiation in mouse mesenchymal C3H10T1/2 cells in vitro. PMID: 19254785
    18. targeted deletion of Wif1 accelerated development of radiation-induced osteosarcomas in vivo PMID: 19307728

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expression highest in heart and lung. Lower in brain and eye.
  • 数据库链接：

    KEGG: mmu:24117

    STRING: 10090.ENSMUSP00000020439

    UniGene: Mm.32831