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  4. Recombinant Mouse Vesicle-associated membrane protein 3 (Vamp3)

Recombinant Mouse Vesicle-associated membrane protein 3 (Vamp3)

  • 货号：
    CSB-YP025782MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025782MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025782MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025782MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025782MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vamp3
  • Uniprot No.：
  • 别名：
    Vamp3; Syb3; Vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptobrevin-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-103
  • 氨基酸序列
    MSTGVPSGSSAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAG ASQFETSAAKLKRKYWWKNCKMWAIGISVLVIIVIIIIVWCVS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
  • 基因功能参考文献：
    1. platelets are capable of a range of endocytosis steps, with VAMP-3 being pivotal in these processes. PMID: 28931526
    2. The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling T-cell receptors to the immune synapse. PMID: 26034069
    3. Although a slight decrease in the rate of recovery of surviving bacteria was observed between 12 h and 36 h post-infection with Brucella melitensis, this was not significant indicating that VAMP3 is not involved in Brucella survival. PMID: 23076244
    4. This important SNARE complex facilitates macrophage adhesion, spreading, and persistent macrophage migration on fibronectin through the delivery of VAMP3-positive membrane with its cargo to expand the plasma membrane. PMID: 21586284
    5. VAMP3 mediates fusion of recycling endosome-derived vesicles with the oligodendroglial plasma membrane in the course of the secretory pathway PMID: 21490207
    6. Cellubrevin alterations and Mycobacterium tuberculosis phagosome maturation arrest. PMID: 11825909
    7. The requirement of vamp3 in phagocytosis in macrophages was determined in vamp3 knockout mice PMID: 12101283
    8. cellubrevin/VAMP-3 is not a requirement for the platelet release reaction in mice. PMID: 12738662
    9. From these results we concluded that cellubrevin-dependent membrane trafficking is involved in TEX101-transport to the surface of male germ cells. PMID: 16678124
    10. transport vesicles containing VAMP3 have distinct membrane fusion kinetics with domains of the plasma membrane that present different t-SNARE proteins. PMID: 17651732

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  • 亚细胞定位：
    Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Synaptobrevin family
  • 数据库链接：

    KEGG: mmu:22319

    STRING: 10090.ENSMUSP00000030797

    UniGene: Mm.273930