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  4. Recombinant Mouse Vesicle-associated membrane protein 1 (Vamp1), partial

Recombinant Mouse Vesicle-associated membrane protein 1 (Vamp1), partial

  • 中文名称：
    小鼠Vamp1重组蛋白
  • 货号：
    CSB-YP720302MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Vamp1重组蛋白
  • 货号：
    CSB-EP720302MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Vamp1重组蛋白
  • 货号：
    CSB-EP720302MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Vamp1重组蛋白
  • 货号：
    CSB-BP720302MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Vamp1重组蛋白
  • 货号：
    CSB-MP720302MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vamp1
  • Uniprot No.：
  • 别名：
    Vamp1; Syb1; Vesicle-associated membrane protein 1; VAMP-1; Synaptobrevin-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the targeting and/or fusion of transport vesicles to their target membrane.
  • 基因功能参考文献：
    1. These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE complex protein VAMP1 (synaptobrevin-1) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens PMID: 27998058
    2. residue 48 of VAMP1 varies frequently between M and I across seventeen closely related primate species, suggesting a potential selective pressure from members of BoNTs for resistance in vertebrates. PMID: 25010769
    3. Genetically regulated VAMP1 expression in the brain may modify both Alzheimer's disease risk and may contribute to Alzheimer's pathophysiology PMID: 25881291
    4. Vesicle release in syb2 KO cultured neurons was massively reduced by a knockdown of syb1, demonstrating that syb1 is responsible for the remaining release activity. PMID: 24944211
    5. A null mutation of Syb1 resulting from a spontaneous, nonsense mutation in mice significantly impairs the function, but not the structure, of the neuromuscular junction. PMID: 21282288
    6. the trigger site in synaptobrevin is crucial for productive SNARE zippering PMID: 20406821
    7. VAMP1 is selectively expressed in the retina and in discrete areas of the brain including the zona incerta and rostral periolivary region in murine lethal wasting disease. PMID: 17102983
    8. CGRP was found to occur in the majority of neurons from rat trigeminal ganglia, together with the three exocytotic SNAREs [SNAP25, syntaxin 1 and the synaptobrevin (Sbr, also known as VAMP) isoforms] and synaptotagmin. PMID: 17666428

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.; [Isoform 2]: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    Synaptobrevin family
  • 组织特异性：
    Highly expressed in the zona incerta and rostral periolivary region of the brain. Other neuroanatomical regions show negligible expression. Expressed in the retina, expression observed in the outer segments of the photoreceptors, in the outer and inner pl
  • 数据库链接：

    KEGG: mmu:22317

    STRING: 10090.ENSMUSP00000032487

    UniGene: Mm.32321