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  4. Recombinant Mouse Tubulinyl-Tyr carboxypeptidase 2 (Vash2)

Recombinant Mouse Tubulinyl-Tyr carboxypeptidase 2 (Vash2)

  • 货号：
    CSB-YP806022MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806022MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806022MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806022MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806022MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vash2
  • Uniprot No.：
  • 别名：
    Vash2; Vashl; Tubulinyl-Tyr carboxypeptidase 2; EC 3.4.17.17; Vasohibin-2; Vasohibin-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-355
  • 氨基酸序列
    MTGSAADTHR CPHPKITKGT RSRSSHARPV SLATSGGSEE EDKDGGVLFH VNKSGFPIDS HTWERMWLHV AKVHPRGGEM VGAIRNAAFL AKPSIPQVPN YRLSMTIPDW LQAIQNYMKT LQYNHTGTQF FEIRKMRPLS GLMETAKEMT RESLPIKCLE AVILGIYLTN GQPSIERFPI SFKTYFSGNY FHHVVLGIYC NGYYGSLGMS RRAELMDKPL TFRTLSDLVF DFEDSYKKYL HTVKKVKIGL YVPHEPHSFQ PIEWKQLVLN VSKMLRADIR KELEKYARDM RMKILKPASA HSPTQVRSRG KSLSPRRRQA SPPRRLGRRD KSPALTEKKV ADLGTLNEVG YQIRI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation.
  • 基因功能参考文献：
    1. High VASH2 expression is associated with diabetes-induced glomerular alterations, particularly impaired filtration barrier and mesangial expansion. PMID: 29641565
    2. These results suggest that VASH2 plays an important role in gastric tumor progression via the accumulation of cancer-associated fibroblasts PMID: 28960674
    3. VASH2 drives breast cancer cells to undergo EMT by activation of the TGFbeta1 pathway and hypoxia dependent repression GATA3-ESR1 pathway, leading to cancer metastasis. PMID: 27867016
    4. VASH1 and VASH2 showed distinctive localization and opposing function on the fetoplacental vascularization. PMID: 25184477
    5. VASH2 may modulate the onset of tumors in the gastrointestinal tract by regulating tumor angiogenesis. PMID: 24885408
    6. Loss of vasohibin-2 is associated with deficient angiogenesis in the termination sprouting front of endothelial cells. PMID: 19204325

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  • 亚细胞定位：
    Cytoplasm. Secreted. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Vasohibin family
  • 组织特异性：
    Preferentially expressed in bone marrow-derived mononuclear cells at the sprouting front.
  • 数据库链接：

    KEGG: mmu:226841

    STRING: 10090.ENSMUSP00000036768

    UniGene: Mm.22856