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  4. Recombinant Mouse Upstream stimulatory factor 2 (Usf2)

Recombinant Mouse Upstream stimulatory factor 2 (Usf2)

  • 中文名称：
    小鼠Usf2重组蛋白
  • 货号：
    CSB-YP720704MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Usf2重组蛋白
  • 货号：
    CSB-EP720704MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Usf2重组蛋白
  • 货号：
    CSB-EP720704MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Usf2重组蛋白
  • 货号：
    CSB-BP720704MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Usf2重组蛋白
  • 货号：
    CSB-MP720704MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Usf2
  • Uniprot No.：
  • 别名：
    Usf2; Upstream stimulatory factor 2; Major late transcription factor 2; Upstream transcription factor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-346
  • 氨基酸序列
    MDMLDPGLDP ASSATAAAAA SHDKGPEAEE GVELQEGGDG PGAEEQTAVA IASVQQAAFG DHNIQYQFRT ESNGGQVTYR VVQVTDGQLD GQGDAAGAVS VVSTAAFAGG QQAVTQVGVD GAAQRPGPAA ASVPTGPAAP FPLAVIQNPF SNGGSPAAEA VSGEARFAYF PASSVGDTTA VSVQTTDQSL QAGGQFYVMM TPQDVLQTGT QRTIAPRTHP YSPKIDGTRT PRDERRRAQH NEVERRRRDK INNWIVQLSK IIPDCHADNS KTGASKGGIL SKACDYIREL RQTNQRMQET FKEAERLQMD NELLRQQIEE LKNENALLRA QLQQHNLEMV GESTRQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
  • 基因功能参考文献：
    1. USF1 and USF2 are important regulatory factors for Alx3 gene expression in different cell types PMID: 23181698
    2. USF-1 but not USF-2 was strongly enriched at Dbeta2 in chromatin from either Rag2-/- double-negative thymocytes or Rag2-/- thymocytes that express a rearranged Tcrb transgene. PMID: 22287717
    3. Blood oxytocin concentrations on d 9 postpartum were also lower in Usf2-/- mice than Usf2+/+ mice PMID: 12907752
    4. transcription factors upstream stimulatory factor (USF) and c-Myc may exert opposing effects on PIGR promoter activity PMID: 14644095
    5. USF2 inhibited cellular transformation by preventing transcriptional repression by c-Myc. PMID: 15541720
    6. Wild-type and USF2 knockout mice exhibited a 2.5-fold stimulation of renal TGF-beta1 expression upon fasting. PMID: 15983197
    7. USF2 might be one of the regulators for the expression of the Runx2 gene in D1 cells. PMID: 16786196
    8. Hyperglycemia stimulated USF2 expression in glomeruli from diabetic mice, associated with TSP1, TGF-beta, and fibronectin in glomeruli, leading to diabetic nephropathy. Overexpression augmented injury. PMID: 17881461
    9. Glucose increases hepatic lipase expression in HepG2 cells via elevation of USF1 and USF2. PMID: 18758746
    10. The C allele of USF2 rs916145 is more frequent in biliary atresa. Decreased USF2 nuclear translocation might play a role in the decreased hepcidin expression in the cholestatic liver injury of the late stage of BA. PMID: 18970934
    11. USF2 promotes renal renin expression and stimulates angiotensin II generation, leading to activation of the intrarenal renin-angiotensin system. PMID: 19004931

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:22282

    STRING: 10090.ENSMUSP00000132256

    UniGene: Mm.322453