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  4. Recombinant Mouse Uncharacterized protein C4orf49 homolog (Osap), partial

Recombinant Mouse Uncharacterized protein C4orf49 homolog (Osap), partial

  • 中文名称：
    小鼠Mgarp重组蛋白
  • 货号：
    CSB-YP855362MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mgarp重组蛋白
  • 货号：
    CSB-EP855362MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mgarp重组蛋白
  • 货号：
    CSB-EP855362MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mgarp重组蛋白
  • 货号：
    CSB-BP855362MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mgarp重组蛋白
  • 货号：
    CSB-MP855362MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mgarp
  • Uniprot No.：
  • 别名：
    Mgarp; Cesp1; Hummr; OsapProtein MGARP; Corneal endothelium-specific protein 1; CESP-1; Hypoxia up-regulated mitochondrial movement regulator protein; Mitochondria-localized glutamic acid-rich protein; Ovary-specific acidic protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology.
  • 基因功能参考文献：
    1. The ratio of motile mitochondria was remarkably decreased in the axons of MGARP-overexpressing cells. PMID: 24323429
    2. These results indicate that HUMMR does not play a key role in mitochondrial dysfunction in the APP/PS1 double transgenic Alzheimer disease mouse PMID: 23900018
    3. MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the hypothalamic-pituitary-gonadal axis. PMID: 21447634
    4. Results identify a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina [MGARP]. PMID: 20107910
    5. Results identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha) [HUMMR]. PMID: 19528298
    6. HUMMR (Hypoxia Upregulated Mitochondrial Movement Regulator) is induced by HIF-1 and regulates mitochondrial distribution and movement in neurons during hypoxia PMID: 19528298
    7. OSAP is prominently expressed in steroidogenic tissues; results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology PMID: 19325000

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  • 亚细胞定位：
    Mitochondrion. Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion (PubMed:19528298).
  • 组织特异性：
    Expressed in the ovary, testis, brain, adrenal glands and the compartments of the visual nervous system. Expressed in corneal endothelium (CE) (at protein level). Expressed in steroidogenic tissues with the highest level of expression observed in the adre
  • 数据库链接：

    KEGG: mmu:67749

    UniGene: Mm.273339