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  4. Recombinant Mouse Tumor necrosis factor ligand superfamily member 13 (Tnfsf13)

Recombinant Mouse Tumor necrosis factor ligand superfamily member 13 (Tnfsf13)

  • 货号：
    CSB-YP887539MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP887539MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP887539MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP887539MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP887539MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfsf13; April; Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; CD antigen CD256
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    96-241
  • 氨基酸序列
    AVLTQ KHKKKHSVLH LVPVNITSKA DSDVTEVMWQ PVLRRGRGLE AQGDIVRVWD TGIYLLYSQV LFHDVTFTMG QVVSREGQGR RETLFRCIRS MPSDPDRAYN SCYSAGVFHL HQGDIITVKI PRANAKLSLS PHGTFLGFVK L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
  • 基因功能参考文献：
    1. p40, a Lactobacillus rhamnosus-derived protein upregulates EGFR-dependent APRIL expression in intestinal epithelial cells, which may contribute to promoting IgA production PMID: 27353252
    2. this study identifies APRIL as a new target involved in B-cell activation, in the maintenance of plasma cell survival and subsequent increased autoantibody production that sustains lupus development in mice PMID: 28267197
    3. Our data indicate that APRIL contributes to fibrotic scar formation after spinal cord injury by mediating the inflammatory response PMID: 27098833
    4. this is the first study to implicate the APRIL signal transduction pathway in the pathogenesis of nephrogenic IgA production. Moreover, our findings identify APRIL as a potential target of therapy. PMID: 26348210
    5. the elevated presence of APRIL and BLyS in B cell-rich areas of chronically inflamed gingiva suggests that these cytokines may contribute to bone loss by promoting the survival and persistence of RANKL-expressing B cells/plasma cells. PMID: 26150532
    6. myelopoiesis dysregulation characterized by an increased proportion of precursor cells occurs in MM patients. Such dysregulation correlates with a stable expression of the MM-promoting factor APRIL in infiltrated BM. PMID: 25753925
    7. B cell activating factor (BAFF) and a proliferation inducing ligand (APRIL) mediate CD40-independent help by memory CD4 T cells in transplantations. PMID: 25496308
    8. Heteromers consisting of one BAFF and two APRIL bind to receptor TACI, BCMA but not to BAFFR. PMID: 25953898
    9. Immunization of mice with a DNA vaccine encoding BAFF or APRIL multitrimers, together with interleukin 12 and membrane-bound HIV-1 Env gp140, induced neutralizing antibodies against tier 1 and tier 2 (vaccine strain) viruses. PMID: 25631080
    10. APRIL mediates peritoneal B-1 cell homeostasis. PMID: 24512739
    11. APRIL selectively enhances axonal growth by activating ERK signaling and PI3-kinase/Akt/GSK-3beta signaling. PMID: 24444792
    12. Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation. PMID: 24100449
    13. The ability of TACI-Fc to activate reverse signalling through BAFF and APRIL, was investigated. PMID: 23620746
    14. CD1d-restricted invariant NKT cell-derived BAFF and APRIL each contribute to survival of plasma cells induced by immunization. PMID: 23797666
    15. The TNF family member APRIL dampens collagen-induced arthritis. PMID: 23178293
    16. NF-kappaB mediates APRIL-induced HoxC4 transcription. PMID: 23178148
    17. APRIL is dispensable for the development of full-blown SLE in NZM mice. PMID: 22127792
    18. Grafted human colorectal tumor growth and metastasis were inhibited while tumor cell apoptosis and necrosis were induced after in vivo APRIL siRNA injection into nude mice. PMID: 22170570
    19. April production, both in the human and mouse systems, peaks in myeloid precursor cells, before dropping in fully mature granulocytes. PMID: 21642598
    20. Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. PMID: 21471524
    21. APRIL inhibits allergic lung inflammation by suppressing c-maf expression and directly reducing IL-13 production in CD4+ T cells. PMID: 21182087
    22. Review. Dendritic cell-derived TNF-family ligand APRIL enhances plasmablast survival and differentiation to plasma cells. PMID: 12354377
    23. Results describe the crystal structure of a proliferation-inducing ligand, APRIL. PMID: 15451660
    24. significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms PMID: 15488762
    25. heparan sulfate proteoglycans (HSPG) serve as a receptor for APRIL or that HSPG binding allows APRIL to interact with a receptor that promotes tumor growth PMID: 15846369
    26. B cell activation factor from the TNF family and proliferation-inducing ligand can modulate the survival of developing B cells in the bone marrow PMID: 16293214
    27. Review. The splice variants, binding specificities, structural determinants for ligand selectivity, and signaling pathways are reviewed. PMID: 16914324
    28. Review. APRIL interactions with BCMA likely govern memory B cell populations. PMID: 16919470
    29. Review. Direct BAFF/APRIL signalling in T cells and/or T cell modulation in response to a BAFF-modified B cell compartment may play an important role in inflammation and immunomodulation. PMID: 16931039
    30. overexpression of BAFF and APRIL may contribute to the development of autoimmune disease PMID: 17947668
    31. APRIL is a critical signal for plasmablast survival that is poorly expressed in the early-life bone marrow compartment. PMID: 18180376
    32. Long-lived memory B cell survival and function are completely independent of APRIL (a proliferation-inducing ligand) or BAFF (B cell-activating factor of the TNF family). Either APRIL or BAFF supports the survival of bone marrow plasma cells in vivo. PMID: 18322170
    33. These results indicate that APRIL affects specific aspects of the anti-influenza response, but plays a limited role in disease recovery. PMID: 18471884
    34. Erythroleukemia in APRIL transgenic mice is characterized by low hematocrits and grossly enlarged spleens with an increased percentage of erythroid precursors. PMID: 18483203
    35. in APRIL(-/-) mice, the incidence of collagen-induced arthritis was significantly reduced compared with WT mice in parallel with diminished levels of antigen-specific IgG2a autoantibody and IL-17 production PMID: 19016524
    36. APRIL blockade resulted in a significant decrease in IL-4 and eotaxin mRNA and IL-4 and KC protein levels in total homogenates and BAL fluid. PMID: 19037968
    37. IL-4 up-regulates APRIL expression through two divergent pathways in mouse macrophages, p38MAPK-CREB and p38MAPK-Stat6. PMID: 19427796

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Tumor necrosis factor family
  • 数据库链接：

    KEGG: mmu:69583

    STRING: 10090.ENSMUSP00000018896

    UniGene: Mm.8983