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  4. Recombinant Mouse Tubulin polymerization-promoting protein (Tppp)

Recombinant Mouse Tubulin polymerization-promoting protein (Tppp)

  • 中文名称：
    小鼠Tppp重组蛋白
  • 货号：
    CSB-YP766513MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tppp重组蛋白
  • 货号：
    CSB-EP766513MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tppp重组蛋白
  • 货号：
    CSB-EP766513MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tppp重组蛋白
  • 货号：
    CSB-BP766513MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tppp重组蛋白
  • 货号：
    CSB-MP766513MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tppp
  • Uniprot No.：
  • 别名：
    Tppp; Tubulin polymerization-promoting protein; TPPP; EC 3.6.5.-; 25 kDa brain-specific protein; TPPP/p25; p25-alpha
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-218
  • 氨基酸序列
    MADSKAKPAK AANKTPPKSP GDPARAAKRL SLESEGANEG ATAAPELSAL EEAFRRFAVH GDTRATGKEM HGKNWSKLCK DCHVIDGKNV TVTDVDIVFS KIKGKSCRTI TFEQFQEALE ELAKKRFKDK SSEEAVREVH RLIEGRAPVI SGVTKAVSSP TVSRLTDTSK FTGSHKERFD QSGKGKGKAG RVDLVDESGY VPGYKHAGTY DQKVQGGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear. In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network. Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6. Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility. Plays a role in cell proliferation by regulating the G1/S-phase transition. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2.
  • 基因功能参考文献：
    1. The present study provides additional support for roles for TPPP in the etiology of depression following early adversity. PMID: 27506655
    2. These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination. PMID: 19606501
    3. LIMK1 phosphorylation of p25 blocks p25 activity, thus promoting microtubule disassembly. PMID: 18028908
    4. A pathway was discovered by which p25 and cdk5 increases the amyloidogenic processing of amyloid precursor protein. PMID: 18341989
  • 亚细胞定位：
    Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    TPPP family
  • 组织特异性：
    Widely expressed with higher expression in brain (at protein level).
  • 数据库链接：

    KEGG: mmu:72948

    STRING: 10090.ENSMUSP00000022057

    UniGene: Mm.39752