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  4. Recombinant Mouse Triggering receptor expressed on myeloid cells 1 (Trem1), partial

Recombinant Mouse Triggering receptor expressed on myeloid cells 1 (Trem1), partial

  • 中文名称：
    小鼠Trem1重组蛋白
  • 货号：
    CSB-YP024404MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trem1重组蛋白
  • 货号：
    CSB-EP024404MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trem1重组蛋白
  • 货号：
    CSB-EP024404MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trem1重组蛋白
  • 货号：
    CSB-BP024404MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trem1重组蛋白
  • 货号：
    CSB-MP024404MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Trem1; Triggering receptor expressed on myeloid cells 1; TREM-1; CD antigen CD354
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis.
  • 基因功能参考文献：
    1. Results suggest that aggravation of VILI by TREM-1 in mice may be associated with TLR4-MyD88-NF-kappaB-dependent signaling. PMID: 29869715
    2. Study using a mouse model of oxygen-induced retinopathy found that TREM-1 inhibition substantially downregulated retinal protein levels of TREM-1 and M-CSF suggesting that TREM-1-dependent suppression of pathological angiogenesis involves M-CSF. PMID: 29730341
    3. TREM-1 is a predictive biomarker of in-stent restenosis and an important mediator of cellular inflammation, migration, and proliferation in vascular smooth muscle cells PMID: 29080545
    4. TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis. PMID: 27762264
    5. TREM-1 aggravates inflammation in acute lung injury by activating NLRP3 inflammasome, and blocking TREM-1 may be a potential therapeutic approach for acute lung injury PMID: 28004759
    6. TREM-1 interventions by means of LP17, LR12 and TREM-1 fusion protein did not ameliorate IR-induced injury. In the human renal transplant cohort, donor and recipient TREM1 gene variant p.Thr25Ser was not associated with DGF, nor with biopsy-proven rejection or death-censored graft failure. We conclude that TREM-1 does not play a major role during experimental renal IR and after kidney transplantation PMID: 27928159
    7. TREM-1 plays an important role in mediating platelet activation. PMID: 28837205
    8. Experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE associated with increased TREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. PMID: 27328755
    9. no significant effect on the severity of psoriasis PMID: 26782119
    10. low expression level of TREM-1 might be a characteristic for tumor-associated macrophages in lung cancer PMID: 27244892
    11. Our findings suggest a novel modulatory role of TREM-1 in the pathogenesis of SLE. sTREM-1 production is a useful diagnostic marker and a molecular target for combination therapy of lupus. PMID: 28089248
    12. these data suggested that TREM-1 signaling pathway may be a therapeutic target to prevent the effects of the inflammatory dendritic cells in systemic lupus erythematosus and miRNA-150 serves as the important regulator PMID: 27940256
    13. The immune receptor Trem1 cooperates with diminished DNA damage response to induce preleukemic stem cell expansion PMID: 27568523
    14. This study is the first to show the regulatory role of TREM-1 in RLRs and TLRs expression. PMID: 27237091
    15. TREM-1 is upregulated in renal inflammation and plays a vital role in driving disease. Thus, TREM-1 blockade emerges as a potential therapeutic avenue for immune-mediated renal diseases such as lupus nephritis PMID: 27083877
    16. in macrophages, oxidized low-density lipoprotein enhanced expression of TREM-1, which amplifies the innate immune response of Toll-like receptor pathway; activation of TREM-1 contributes to atherogenesis process by enhancing proinflammatory cytokine production and foam cell formation. PMID: 26277357
    17. High Expression Levels of Trigger Receptor Expressed on Myeloid Cells-1 on Neutrophils Associated with Increased Severity of Acute Pancreatitis in Mice PMID: 26250893
    18. a novel positive feedback cycle mediated by TREM-1 and GM-CSF was revealed to enhance macrophage polarization under unilateral ureteral obstruction. PMID: 24918157
    19. TREM-1-mediated innate immune response played an essential role in the activation of neutrophils and Streptococcus suis clearance. PMID: 26056380
    20. Data indicate that triggering receptor expressed on myeloid cells-1(TREM-1) inhibition improves heart function after myocardial infarction (MI). PMID: 25840803
    21. TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice PMID: 24959004
    22. TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PMID: 24453980
    23. Data indicate that triggering receptor expressed on myeloid cells 1 (TREM-1) induces anti-apoptotic protein Bcl-2 and prolongs macrophage survival. PMID: 24711453
    24. Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia. PMID: 24752755
    25. expression of membrane and soluble form is regulated by TLR9 activation with CpG-ODN PMID: 23475790
    26. Data indicate a positive correlation between serum levels of soluble TREM-1 (sTREM-1) and disease severity in infected patients as well as in experimentally infected mice. PMID: 23571837
    27. TREM-1-mediated bacterial clearance in the small intestine. PMID: 24396044
    28. TREM-1 plays critical roles in colon inflammation and tumor. PMID: 23810411
    29. TREM-1 influences chronic heart rejection by regulating the infiltration and differentiation of CD4(+) lymphocytes. PMID: 23463907
    30. These data define a new function for TREM-1 in neutrophil migration across airway epithelial cells and suggest that it amplifies inflammation through targeted neutrophil migration into the lung. PMID: 23241959
    31. Findings offer causal evidence that TREM-1 is a pivotal determinant of Kupffer cell activation in liver carcinogenesis, deepening mechanistic insights into how chronic inflammation underpins the development and progression of liver cancer. PMID: 22719066
    32. TREM-1 was not expressed on lymphocytes but emerged on the cell surface of neutrophils and peritoneal macrophages. PMID: 22055202
    33. TREM-1 modulates the immune response directed against A. fumigatus during experimental fungal asthma. PMID: 21592044
    34. The present study has demonstrated for the first time the detailed mechanism for the basal and LPS-induced expression of TREM-1, an amplifying molecule in inflammation. PMID: 21683719
    35. this study provides the fi rst evidence that TREM-1 functions as an in fl ammatory ampli fi er in P. aeruginosa keratitis by modulating TLR signaling and Th1/Th2 responses. PMID: 21555403
    36. In this study, the s delineate the role of the innate immunoreceptor TREM-1 in the parasite Schistosoma mansoni infection model from early to late (chronic) phases of infection. PMID: 21332515
    37. Calcitonin gene-related peptide can regulate the LPS-induced macrophages synthesis and secretion of TREM-1. PMID: 20197606
    38. The expression of TREM-1 in response to lipopolysaccharides and bacteria Pseudomonas aeruginosa is inhibited by PGD(2) and cyclopentanone prostaglandins PGJ(2) and 15-dPGJ(2). PMID: 20797396
    39. crystal structure of the mouse TREM-1 extracellular domain at 1.76A resolution PMID: 15561137
    40. Regulation of TREM-1 and the soluble form of TREM-1 expression by prostaglandin E2 may modulate the inflammatory response to microbial pathogens PMID: 17202378
    41. septic shock induced could be attenuated by administering a Trem1-Fc fusion protein PMID: 19120482
    42. TREM-1 ligation contributes to the pathology of autoimmune arthritis. PMID: 19479878
    43. TREM-1 enhances responsiveness of alveolar macrophages to S. pneumoniae in vitro, and augments the early pulmonary inflammatory response PMID: 19596984

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:58217

    STRING: 10090.ENSMUSP00000038636

    UniGene: Mm.248352