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  4. Recombinant Mouse Transmembrane protein 119 (Tmem119), partial

Recombinant Mouse Transmembrane protein 119 (Tmem119), partial

  • 货号：
    CSB-YP023686MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023686MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023686MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023686MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023686MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tmem119
  • Uniprot No.：
  • 别名：
    Tmem119; Transmembrane protein 119; Osteoblast induction factor; OBIF
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation.
  • 基因功能参考文献：
    1. The first highly pure RNAseq profiles of microglia during development and after immune challenge show Tmem119 gene expression increases during development until P14 and then stabilizes. PMID: 26884166
    2. Obif plays essential roles in the development of multiple tissues, is required for bone mineralization and spermatogenesis. PMID: 26207632
    3. BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4 PMID: 24362451
    4. Data show that Tmem119 promotes the differentiation of myoblasts into osteoblasts and the interaction with the BMP signaling pathway likely occurs downstream of Runx2 and Osterix in myoblasts. PMID: 22579779
    5. Obif plays an essential role in bone formation through regulating osteoblastogenesis. PMID: 22416756
    6. Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway. PMID: 21239498
    7. Study identifies a novel gene, obif (osteoblast induction factor), encoding a transmembrane protein that is predominantly expressed in osteoblasts. PMID: 20025746

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Endoplasmic reticulum membrane.
  • 组织特异性：
    Expressed in spermatocytes and spermatids in the developing testis (at protein level). Expressed in the brain, heart, lung, spleen, skeletal muscle, ovary, testis and epididymis. Predominantly expressed in osteoblasts.
  • 数据库链接：

    KEGG: mmu:231633

    STRING: 10090.ENSMUSP00000070551

    UniGene: Mm.41681