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  4. Recombinant Mouse Transcription initiation factor TFIID subunit 7-like (Taf7l)

Recombinant Mouse Transcription initiation factor TFIID subunit 7-like (Taf7l)

  • 中文名称：
    小鼠Taf7l重组蛋白
  • 货号：
    CSB-YP861534MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Taf7l重组蛋白
  • 货号：
    CSB-EP861534MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Taf7l重组蛋白
  • 货号：
    CSB-EP861534MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Taf7l重组蛋白
  • 货号：
    CSB-BP861534MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Taf7l重组蛋白
  • 货号：
    CSB-MP861534MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Taf7l
  • Uniprot No.：
  • 别名：
    Taf7l; Taf2q; Transcription initiation factor TFIID subunit 7-like; TATA box binding protein-associated factor RNA polymerase II subunit Q; TATA box-binding protein-associated factor 50 kDa; Transcription initiation factor TFIID 50 kDa subunit
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-471
  • 氨基酸序列
    MERGEEAPTE GAPPEGALVE AKAPVIPEAP ATDVSTTEEA GSKEPQVPSG PRPEGAGDTC DTRGARGPPT PGRAKSQKTP RQGTARCQTL ESAMRSMSVR LECHDVEEQF ILRLPPEQAY AVRKIIHSRN AAWKDKLKID FSPDGHHAVV QVDNVSLPAK LVNLPCVIGS LKTIDRKTFY KTADVSQMLV CSPEGEPHSP PEEPVVSTGP TVIGISEGKA ERKKYNWKHG ITPPLKNVRK KRFRKTTKKL PDVKQVDEIN FSEYTQSPSV EKEVKRLLYS DAEAVSVRWE VVDDDDAKEI ESQGSMPTTP GISQMGGASL SDYDVFREMM GDSGSNSNDV EEKSNEGDDD DDEDEDDEDY GNEKEEEETD NSEEELEKEL QAKFNEFSLH EADQDYSSIT MAIQKLIFIK EKRLQMIYKK AQRQKELLRK VENLTLKRHF QNVLGKLNIM EKEKCEQIYH LQEQLKCFLK E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis.
  • 基因功能参考文献：
    1. Suggest that TAF7L plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARgamma and promoters as a component of the core transcriptional machinery. PMID: 23326641
    2. the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during brown adipose tissue lineage specification PMID: 24876128
    3. TAF7L associates with TRF2 both in vitro and in testis, suggesting that TAF7L likely cooperates directly with TRF2 at promoters of a subset of postmeiotic genes to regulate spermiogenesis. PMID: 24082143
    4. TAF7L replaces TAF7 as a TFIID subunit in late pachytene spermatocytes and in haploid cells. PMID: 12665565
    5. While spermatogenesis was completed in Taf7l(-/Y) mice, the weight of Taf7l(-/Y) testis decreased. Mutant epididymal sperm exhibited abnormal morphology. Sperm motility was significantly reduced, and Taf7l(-/Y) males were fertile with reduced litter size. PMID: 17242199
    6. Transcripts highly enriched in neonatal ovaries. PMID: 17660561
    7. Disruption of Taf7l causes reduced testis weight, decreased sperm production and motility, and abnormal morphology PMID: 17242199

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids.
  • 蛋白家族：
    TAF7 family
  • 组织特异性：
    Testis-specific (at protein level). Expressed during spermatogenesis from spermatogonia stage up to the stage of round spermatids.
  • 数据库链接：

    KEGG: mmu:74469

    STRING: 10090.ENSMUSP00000009740

    UniGene: Mm.103259