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  4. Recombinant Mouse Transcription factor SOX-17 (Sox17)

Recombinant Mouse Transcription factor SOX-17 (Sox17)

  • 货号：
    CSB-YP723413MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP723413MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP723413MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP723413MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP723413MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sox17; Sox-17; Transcription factor SOX-17
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-419
  • 氨基酸序列
    MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA SSGAPAGTSG RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKALT LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR VEGGFLHALV EPQAGALGPE GGRVAMDGLG LPFPEPGYPA GPPLMSPHMG PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP LPGDCPAAGT YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG TESNQPTELL GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI SSVVSDASSA VYYCNYPDI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells.; Has no DNA-binding activity, and does not function as transcriptional activator.
  • 基因功能参考文献：
    1. Enforced expression of Sox17 increases expression of morphogenesis genes and promotes integration of transplanted converted cells into injured vessels. PMID: 28091527
    2. The defective gallbladder contraction positively correlated with the severity of embryonic hepatitis in Sox17(+/-) embryos, suggesting a potential contribution of embryonic cholecystitis and fetal gallbladder contraction in the early pathogenesis of congenital biliary atresia. PMID: 28432216
    3. Sox17 disruption in epithelial and stromal compartments led to inhibition of endometrial adenogenesis and a loss of reproductive capacity. Epithelium-specific Sox17 disruption resulted in normal adenogenesis although reproductive capacity remained impaired. Non-epithelial, Sox17-positive cells are necessary for adenogenesis and endometrial glands require Sox17 to properly function. PMID: 27102016
    4. SOX-17 transcription factor is indispensable in developmental angiogenesis and as a positive feedback regulator of VEGF signaling. PMID: 27528602
    5. findings indicate the role of Sry-related HMG box gene-17 (Sox17) in uterine receptivity to embryo implantation. PMID: 27053385
    6. combined deletion of Sox7, Sox17, and Sox18 at the onset of retinal angiogenesis leads to a dense capillary plexus with a nearly complete loss of radial arteries and veins, whereas the presence of a single Sox17 allele largely restores arterial identity PMID: 26630461
    7. Sox17 inhibition of Runx1 and Gata2 maintains endothelial fate in endothelial-to-haematopoietic transition PMID: 26204127
    8. Sox17 deficiency in mouse can induce intracranial aneurysm under hypertensive conditions, suggesting Sox17 deficiency as a potential genetic factor for IA formation. PMID: 25596186
    9. These results identify a novel role for Sox17 in adult liver as a modulator of the metabolic adaptation to fasting. PMID: 25141153
    10. the transcription factor SOX17, which is activated in prospective definitive endoderm cells before intercalation, is necessary for gut endoderm morphogenesis and the assembly of the basement membrane that separates gut endoderm from mesoderm. PMID: 25419850
    11. Hhex and Cer1 are indispensable components of the Sox17 pathway for cardiopoiesis. PMID: 24585688
    12. A regulatory network, incluing Sox17 and the retinoic acid receptor, controls nephrocan expression and midgut patterning. PMID: 25209250
    13. Sox17 promotes endothelial migration. It destabilizes endothelial junctions, rearranges the cytoskeleton, and upregulates several genes expressed in tip cells. The Notch pathway regulates Sox17 expression mainly at the post-transcriptional level. PMID: 24755984
    14. SoxF proteins, especially Sox17, contribute to the maintenance of cell clusters containing hematopoietic stem cells in the midgestation aorta-gonad-mesonephros region PMID: 24662049
    15. Sox17 is a component of the complex signaling network that orchestrates arterial/venous specification. PMID: 24153254
    16. Sox17 is required for normal formation of the pulmonary vasculature and postnatal cardiovascular homeostasis. PMID: 24418654
    17. This study demonstrate that Sox17 expression is highest in newly generated oligodendrocytes under pathological conditions and could be used as a marker of oligodendrocyte regeneration. PMID: 23918253
    18. Expression of Kras(G12D) and SOX17 in mice induces development of metaplasias with a biliary phenotype containing tuft cells. Expression of SOX17 induces pancreatitis and promotes Kras(G12D)-induced tumorigenesis in mice. PMID: 23999170
    19. Our study thus reveals a biphasic effect of Sox17 on cell survival and oligodendrocyte formation in developing white matter, and that its potentiation of oligodendrocyte survival in the adult confers resistance to injury and myelin loss. PMID: 23884956
    20. Sox17 lineage tracing in the definitive endoderm shows a cell-autonomous requirement for beta-catenin in midgut and hindgut formation. PMID: 23824574
    21. Sox17 act as a key regulator of haemogenic endothelial and haematopoietic development. PMID: 23604320
    22. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. PMID: 23474895
    23. findings establish Sox17 as a key regulator of tumor angiogenesis and tumor progression. PMID: 23241958
    24. Data indicate that HDAC1 affects cardiovascular and more specifically cardiomyocyte differentiation in embryonic stem cells by controlling expression of SOX17 and BMP2 during early differentiation. PMID: 22984607
    25. SOX17 is highly expressed in proliferating epithelial cells of the gallbladder primordium, but not in fetal hepatocytes during mid- and late-organogenic stages. Haploinsufficiency results in perinatal biliary atresia. PMID: 23293295
    26. Sox17 is expressed in progenitor cells derived from two different germ layers. PMID: 22865702
    27. Disrupted SOXF function results in epidermolysis bullosa-like skin phenotypes. PMID: 22962592
    28. Sox17 represents a potentially novel mediator of progesterone receptor action in the murine uterus. PMID: 22638070
    29. Sox17 mutants fail to establish left-right asymmetry and show aberrant gut endoderm morphogenesis. PMID: 22412348
    30. The promoter regions of Sox17 and Foxa2 are subjected to histone acetylation regulation. PMID: 22132182
    31. Sox17 might be a key transcription factor controlling CD133 expression, and that it might also play a role in the control of gastric tumor progression. PMID: 21457403
    32. Activation of FGFR(IIIc) isoforms promotes activin-induced mesendoderm development in mouse embryonic stem cells and reduces Sox17 expression. PMID: 21513905
    33. Data reveal that many genes related to heart development were downregulated in Sox17-null embryos. PMID: 21305474
    34. a role for SOX17 in the maintenance of primitive endoderm epithelial integrity, with the absence of SOX17 leading to premature delamination and migration of parietal endoderm. PMID: 21146513
    35. Data demonstrate that Sox17 can directly regulate Wnt/beta-catenin-dependent transcription of the Lef-1 promoter and reveal new context-dependent binding sites in the Lef-1 promoter that facilitate protein-protein interactions between Sox17 and TCF4. PMID: 20802155
    36. these findings show that Sox17 functions cell-autonomously to specify gallbladder/bile-duct in the mouse embryo. PMID: 19913509
    37. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. PMID: 20123909
    38. important role of Sox17 in endoderm development in the mouse PMID: 11973269
    39. SOX7 and SOX17 bound specifically to two SOX-binding sites within the Lama1 enhancer, and that these SOX-binding sites functioned synergistically to confer the trans-activation by SOX7 and SOX17 PMID: 15220343
    40. Sox17, Id2, HNF3beta/Foxa2, and GATA4, were expressed in both embryoid bodies and gut-like structures PMID: 16210401
    41. Sox17 induced plasticity of respiratory epithelial cells, reprogramming alveolar cells into epithelial cells with characteristics more typical of the proximal airway. PMID: 16574095
    42. Results indicate that Sox17 and Sox18, and possibly all three SoxF genes, are cooperatively involved in mammalian vascular development. PMID: 16895970
    43. Sox17 plays important roles in controlling both oligodendrocyte progenitor cell cycle exit and differentiation. PMID: 16988043
    44. Sox17 has a critical role in specification of cardiac mesoderm in embryonic stem cells PMID: 17360443
    45. Sox17/Sox18 double-null embryos showed more severe defects in formation of anterior dorsal aorta and head/cervical microvasculature, and in some cases, aberrant differentiation of endocardial cells and defective fusion of the endocardial tube PMID: 17610846
    46. Sox17 is required for the maintenance of fetal and neonatal hematopoietic stem cells (HSCs) and distinguishes their transcriptional regulation from adult HSCs. PMID: 17655922
    47. Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts. PMID: 17875931
    48. These results indicate a substantial involvement of Sox17 in the late stage of extraembryonic endoderm differentiation in vitro. PMID: 17940068
    49. SOX17-Chromatin immunoprecipitation identified zinc finger protein 202 (Zfp202) as a direct target of SOX17 during endoderm differentiation of F9 embryonal carcinoma cells. PMID: 18523156
    50. the details of initial crystallization attempts with the HMG domain of mouse Sox17 (mSox17-HMG) with a 16-mer DNA element PMID: 19052383

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Detected in lung and testis. Detected in endothelial cells around small and large arteries in newborns and adults, but is barely detectable in veins (at protein level). Detected in lung and testis.
  • 数据库链接：

    KEGG: mmu:20671

    STRING: 10090.ENSMUSP00000027035

    UniGene: Mm.279103