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  4. Recombinant Mouse Transcription factor Ovo-like 2 (Ovol2)

Recombinant Mouse Transcription factor Ovo-like 2 (Ovol2)

  • 中文名称：
    小鼠Ovol2重组蛋白
  • 货号：
    CSB-YP810615MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ovol2重组蛋白
  • 货号：
    CSB-EP810615MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ovol2重组蛋白
  • 货号：
    CSB-EP810615MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ovol2重组蛋白
  • 货号：
    CSB-BP810615MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ovol2重组蛋白
  • 货号：
    CSB-MP810615MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ovol2
  • Uniprot No.：
  • 别名：
    Ovol2; Ovo2; Zfp339; Znf339; Transcription factor Ovo-like 2; mOvo2; Zinc finger OVO2; Zinc finger protein 339; Zinc finger protein mOVO
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-274
  • 氨基酸序列
    MPKVFLVKRR SPGVSVRSWD ELPDDKRADT YIPVSLGCLL RDPPEDCRSD GGSSSGCSSS AGEPGGAESS SSPRAPEPET PELHDAQGTD GHLAAMQRPV ARSKIKFTTG TCDNSVIHNC DLCGKSFRLQ RMLNRHLKCH NQVKRHLCTF CGKGFNDTFD LKRHVRTHTG IRPYKCEVCN KAFTQRCSLE SHLKKIHGVQ QQYAYKQRRD KLYVCEDCGY TGPTQEDLYL HVNSDHPGST FLKKTSKKLA ALMQNKLTSP LQENSTLSEE EEKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos.
  • 基因功能参考文献：
    1. Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported. PMID: 27310661
    2. OVOL2 is a colorectal tumor suppressor that blocks WNT signaling by facilitating the recruitment of histone deacetylase 1 to the TCF4-beta-catenin complex. PMID: 26619963
    3. a Grhl2/Ovol2 network controls Cldn4 and Rab25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia PMID: 25788534
    4. We show that ER71 directly interacts with OVOL2 and that such interaction is critical for FLK1(+) cell generation and their differentiation into downstream cell lineages. PMID: 25267199
    5. Deletion of Ovol2 blocks mammary ductal morphogenesis, depletes stem and progenitor cell reservoirs, and leads epithelial cells to undergo EMT . PMID: 24735879
    6. Ovol2 acts downstream of the BMP pathway in the cell fate decision between neuroectoderm and mesendoderm to ensure proper germ layer development. PMID: 23319585
    7. Ovol2/MOVO may play an important role in the XY body during spermatogenesis, possibly in the processes of XY body formation and meiotic sex chromosome inactivation. PMID: 21636736
    8. Ovol2 transcription was dramatically reduced in testes from blind-sterile mice, suggesting that Ovol2 is expressed in male germ cells PMID: 12213202
    9. Ovol2 is a key regulator of neural development and reveal a previously unexplored role for Ovo genes in mammalian embryogenesis. PMID: 16423343
    10. Expression of Ovol2 was up-regulated in Ovol1-deficient epidermis; Ovol1 represses the activity of Ovol2 promoter in a DNA binding-dependent manner identifying Ovol2 as a downstream target of Ovol1. PMID: 17049212
    11. Ovol2 may play a critical role in vascular angiogenesis during early embryogenesis PMID: 17573777

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed highly in testis, specifically in spermatocytes. Expressed also in skin and at lower levels in the ovary.
  • 数据库链接：

    KEGG: mmu:107586

    STRING: 10090.ENSMUSP00000044026

    UniGene: Mm.252750