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  4. Recombinant Mouse Transcription factor Maf (Maf)

Recombinant Mouse Transcription factor Maf (Maf)

  • 货号：
    CSB-YP013312MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013312MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP013312MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013312MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013312MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Maf; Maf2; Transcription factor Maf; Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-370
  • 氨基酸序列
    MASELAMNNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI AGGSLSSTPM STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ LNPEALGFSP EDAVEALISN SHQLQGGFDG YARGAQQLAA AAGAGAGASL GGSGEEMGPA AAVVSAVIAA AAAQSGAAPH YHHHHHHAAG HHHHPTAGAP GAAGGASASA SGAGGAGGGG PASAGGGGGG GGGGGTAGAG GALHPHHAAG GLHFDDRFSD EQLVTMSVRE LNRQLRGVSK EEVIRLKQKR RTLKNRGYAQ SCRFKRVQQR HVLESEKNQL LQQVDHLKQE ISRLVRERDA YKEKYEKLVS NGFRENGSSS DNPSSPEFFM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding.
  • 基因功能参考文献：
    1. these data demonstrate that c-Maf is an indispensable yet constitutive transcription factor for IL-10 gene expression in LPS-activated B cells PMID: 29974486
    2. The control of cMaf expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge. PMID: 29484383
    3. results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iTreg-TH17 homeostasis PMID: 29414937
    4. c-Maf is a critical transcription factor regulating T-cell specialization in mice, essential for generation of both RORgammat(+) Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf is induced in Tregs by IL-6 and TGF-beta. PMID: 29127150
    5. interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis PMID: 26969892
    6. HERC4 mediates c-Maf ubiquitination and delays growth of multiple myeloma. PMID: 26825710
    7. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. PMID: 26719333
    8. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. PMID: 25993510
    9. endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function PMID: 25763640
    10. The melanoma microenvironment contributes to skewing of CD8 T cell differentiation programs, in part by TGFbeta/IL-6-mediated induction of Maf. PMID: 26139534
    11. Sox5 physically associates with c-Maf via the HMG domain of Sox5 and DNA-binding domain of c-Maf, and Sox5 together with c-Maf directly activates the promoter of RORgammat in CD4(+) T cells. PMID: 25073789
    12. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. PMID: 24319262
    13. Translocations between IGH and MAF may arise only in the absence of close proximity to the more frequent partners in multiple myeloma. PMID: 23460268
    14. p53 regulates lens differentiation through modulation of two important transcription factors, c-Maf and Prox1. PMID: 22827438
    15. inappropriate expression of the fiber cell markers c-maf and Prox1 also occurred, indicating a failure of appropriate lens fiber cell differentiation accompanied by altered lens cell proliferation and cell death. PMID: 22491411
    16. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. PMID: 22001828
    17. This study demonistrated that c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. PMID: 22514301
    18. findings show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function PMID: 22345400
    19. Data establish a novel regulatory role for Pax6 during lens development, link together the Pax6/c-Maf/crystallin regulatory network, and suggest a novel type of GRN subcircuit that controls a major part of embryonic lens development. PMID: 21998302
    20. c-Maf is crucial for definitive erythropoiesis in fetal liver, playing an important role in macrophages that constitute erythroblastic islands. PMID: 21628412
    21. c-Maf is important for the development of memory Th cells, particularly memory Th17 cells and Th1 cells. PMID: 21402704
    22. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein PMID: 21362551
    23. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis. PMID: 21224354
    24. the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21 promoters, which resulted in the generation of Tr1 cells PMID: 20676095
    25. c-Maf interacts with Ubc9 & PIAS1. c-Maf can be SUMOylated at Lys-33 in Th2 cells. SUMOylation attenuates its transcriptional activity. PMID: 20127678
    26. c-Maf induces IL-21 production directly in CD4(+) T cells by activating IL-21P and the CNS-2 enhancer and that TGF-beta suppresses c-Maf-induced IL-21 production in CD4(+) T cells. PMID: 20042469
    27. c-maf promotion of Th2 cytokine production is dependent on CD25 PMID: 12271139
    28. c-Maf is a potent activator of IL-10 gene expression in monocytes/macrophages that, when overexpressed, selectively inhibits IL-12p40 and p35 gene transcription. PMID: 12421951
    29. maf has a role in murine cataract and results in selective alteration in DNA binding PMID: 12620964
    30. c-Maf is required for normal chondrocyte differentiation. PMID: 14512017
    31. These findings suggest that expression of the c-maf gene may be involved in the embryological development and/or cell differentiation of kidney and liver cells. PMID: 15249232
    32. tissue-specific expression of alphaA-crystallin is regulated by recruitment of Pax6 and c-Maf PMID: 16023139
    33. localization of cyclin D1 in developing lens cells of c-maf knockouts; many cyclin D1-positive nuclei were observed in lens epithelial cells and posterior lens cells; results consistent with c-maf role in regulation of cyclin D1 in developing lens cells PMID: 16325892
    34. Taken together, these data indicate that the CTGF gene is a target of c-Maf and Lc-Maf in cartilage development. PMID: 16343439
    35. results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation PMID: 16424013
    36. Data demonstrate a novel mechanism of Pax6, c-Maf and CREB function, through regulation of chromatin-remodeling enzymes, and suggest a multistage model for the activation of alphaA-crystallin during lens differentiation. PMID: 16675956
    37. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney PMID: 16890189
    38. c-Maf D90V enhances p300 recruitment in a cell-type dependent manner. PMID: 17374726
    39. Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene PMID: 17901057
    40. ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells. PMID: 19098919
    41. Results suggest that Lc-Maf may affect the process of endochondral ossification by participating in the regulation of Col27a1 expression. PMID: 19414009
    42. c-Maf is required for the F4/80 expression in macrophages in vivo. PMID: 19539733
    43. IL-27-driven c-Maf expression transactivates IL-21 production, which acts as an autocrine growth factor for the expansion and/or maintenance of IL-27-induced Tr1 cells PMID: 19570826

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    BZIP family, Maf subfamily
  • 组织特异性：
    Expressed in tubules of the renal cortex and hepatocytes. Expressed in the lens (at protein level). Expressed in pancreatic islets and endothelial cells.
  • 数据库链接：

    KEGG: mmu:17132

    STRING: 10090.ENSMUSP00000104732

    UniGene: Mm.275549