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  4. Recombinant Mouse Toll-like receptor 6 (Tlr6), partial

Recombinant Mouse Toll-like receptor 6 (Tlr6), partial

  • 货号：
    CSB-YP023605MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023605MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023605MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023605MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023605MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tlr6; Toll-like receptor 6; EC 3.2.2.6; CD antigen CD286
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.
  • 基因功能参考文献：
    1. findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium PMID: 28317806
    2. the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined. PMID: 26578650
    3. TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition. PMID: 26940740
    4. Dengue virus NS1 protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection PMID: 26226614
    5. Hepatic expression of Tlr6, but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria. PMID: 25056943
    6. Transmembrane oligomeric form of Vibrio cholerae cytolysin (VCC) triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages. PMID: 25431887
    7. The inhibition of TLR receptors 2 and 6 in the presence of their specific ligands restored the ability of the spheroids to bind to the endometrial cells. PMID: 24621922
    8. The results demonstrate that inflammatory responses caused by ZNPs-activated macrophages strongly depend on TLR6-mediated MAPK signalling. PMID: 24593842
    9. TLR6 on bone marrow dendritic cells can sense Mycobacterium avium and this receptor is required for full resistance to M. avium infections. PMID: 23716075
    10. The toll-like receptor 2/6 agonist MALP-2 promotes reendothelialization and inhibits neointima formation after experimental vascular injury via enhanced proliferation and migration of endothelial cells. PMID: 23868938
    11. In this study, we report that transmembrane domain (TMD)-derived peptides from TLR2 and TLR6 specifically inhibit TLR2 activation PMID: 23677476
    12. the results presented here indicate that TLR6 is required to trigger innate immune responses against B. abortus in vivo and is required for the full activation of dendritic cells to induce robust proinflammatory cytokine production. PMID: 23460520
    13. TLR6 activation is critical for IL-23 production and Th17 responses, which both regulate the allergic inflammatory response in chronic fungal-induced asthma. PMID: 22005301
    14. Although targeted deletion of TLR6 does not affect the incidence or severity of myelin oligodendrocyte glycoprotein (MOG)35-55 peptide-induced autoimmune encephalomyelitis, signaling via MyD88 is necessary. PMID: 21685327
    15. data demonstrate the requirement for TLRs in inducible resistance against pneumonia and reveal a remarkable, unanticipated synergistic interaction of TLR2/6 and TLR9 PMID: 21482737
    16. TLR6 plays a pivotal role in the development and severity of hypersensitivity pneumonitis via its role in IL-17A production. PMID: 20070409
    17. TLR2 and TLR6 deletions affected lipid droplet formation in bacterium-bearing cells only partially, suggesting the involvement of alternative receptors of the innate immune response besides TLR2/6 for Mycobacterium leprae recognition by macrophages. PMID: 19952355
    18. Differential recognition of structural details of bacterial lipopeptides by toll-like receptors 2 and 6. PMID: 12432564
    19. TLR6 KO mice were not different from wild-type mice in terms of pulmonary tuberculosis histopathology, mRNA expression and CFU assay PMID: 12825894
    20. Porin of Shigella dysenteriae type 1 increased the mRNA levels for TLR2 and TLR6 of peritoneal cavity cells, implicating that coexpression of TLR2 and TLR6 is essential as a combinatorial repertoire for recognition of porin by the B-1 cells PMID: 15482852
    21. decreased mRNA expression during Salmonella enterica serovar Typhimurium sublethal infection PMID: 15731092
    22. Recognition of C. albicans by TLR6 modulated the balance between Th1 and Th2 cytokines, and TLR6 knock-out mice displayed a defective production of IL-10 and an increased IFN-gamma release. PMID: 18036178
    23. Toll-like receptors 2 and 6 signaling from the phagosome is enhanced by mannose-binding lectin PMID: 18180310
    24. TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation. PMID: 18424724
    25. The s show that TLR6 associates with TLR2 to induce tolerogenic DC and regulatory type-1 T cells selectively secreting IL-10. PMID: 18854239
    26. Mice deficient in TLR6 are susceptible to experimental autoimmune encephalomyelitis PMID: 19211042
    27. Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis PMID: 19458089
    28. Analyses of the cytokine production profile of macrophages isolated from knockout mice deficient in TLRs or in MyD88 and TRIF revealed a critical role for TLR2, TLR6 and MyD88 in the production of IFNbeta-independent chemokines. PMID: 19543380

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus.
  • 蛋白家族：
    Toll-like receptor family
  • 组织特异性：
    Detected in thymus, spleen, ovary and lung. Expressed in macrohpages.
  • 数据库链接：

    KEGG: mmu:21899

    STRING: 10090.ENSMUSP00000062096

    UniGene: Mm.42146