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  4. Recombinant Mouse Toll-like receptor 1 (Tlr1), partial

Recombinant Mouse Toll-like receptor 1 (Tlr1), partial

  • 货号：
    CSB-YP023599MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023599MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023599MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023599MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023599MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tlr1; Toll-like receptor 1; EC 3.2.2.6; Toll/interleukin-1 receptor-like protein; TIL; CD antigen CD281
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen.
  • 基因功能参考文献：
    1. These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response. PMID: 27267778
    2. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination, modulated by BCR and CD40 in mounting of T-cell independent antibody responses. PMID: 25536171
    3. TLR9 modulates TLR1 expression in Leishmania major-infected macrophages. PMID: 25911242
    4. Postradiotherapeutic NO production was dependent on TLR1 gene expression. Although iNOS activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression. PMID: 25632046
    5. lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface. PMID: 24860120
    6. We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines. Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6-signaling PMID: 25184331
    7. IkappaB-zeta regulates TLR-mediated CSR by inducing AID PMID: 25124037
    8. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes. PMID: 24091496
    9. role in TH17 immunity through the activation and recruitment of dendritic cells PMID: 23443468
    10. Identify TLR1 as a critical innate receptor for protective intestinal T(H)17 immunity. PMID: 22778390
    11. Graphene significantly stimulates the secretion of cytokines/chemokines via TLR- and NF-kappaB-related signaling pathways PMID: 22796167
    12. Innate immune detection of Aspergillus fumigatus is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice. PMID: 22315281
    13. a dominant role for TLR1/TLR2 heterodimers in the induction of the early inflammatory response by Borrelia spirochetes in humans PMID: 21998742
    14. These data suggest that TLR-2, but not TLR-1, plays a role in neonatal hypoxic-ischemic brain injury. PMID: 21569241
    15. Although Tlr1-, Tlr4- and Tlr6-deficient C57BL/6 mice all show normal susceptibility to autoimmune encephalomyelitis, signs are alleviated in female C57BL/6 mice. PMID: 21685327
    16. Tlr1 is involved in the recognition of the lipid configuration of native mycobacterial lipoprotein as well as several triacylated lipopeptides. PMID: 12077222
    17. These data indicate that TLR1 and TLR2 are required for lipoprotein recognition and that defects in the TLR1/2 signaling pathway may account for human hyporesponsiveness to Borrelia burgdorferi OspA vaccination. PMID: 12091878
    18. Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 is activated by saturated fatty acid and inhibited by polyunsaturated fatty acid PMID: 14966134
    19. increased mRNA levels during Salmonella enterica serovar Typhimurium sublethal infection PMID: 15731092
    20. beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling PMID: 16378096
    21. Contrary to the current model, distinct lipopeptides are recognized by TLR2 in a TLR1- and TLR6-independent manner PMID: 16455646
    22. Intestinal enteroendocrine cells express TLRs which may be involved in innate immune responses. PMID: 17395901
    23. JNK1, but not JNK2, activity regulates the expression of the tlr1 gene in the macrophage cell line RAW264.7, as well as in primary CD11b(+) cells. PMID: 17664270
    24. TLR1 is involved in the regulation of mechanisms that impinge on diabetes development in the NOD mouse. PMID: 17785827
    25. TLR1 is not involved in the recognition of C. albicans, and TLR1 knock-out (TLR1-/-) mice showed a normal susceptibility to disseminated candidiasis. PMID: 18036178
    26. Microarray analysis of in vivo Borrelia burgdorferi gene expression in murine skin showed that several genes were altered in TLR1/2-deficient animals compared with wild-type mice. PMID: 19754309

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus.
  • 蛋白家族：
    Toll-like receptor family
  • 数据库链接：

    KEGG: mmu:21897

    STRING: 10090.ENSMUSP00000060793

    UniGene: Mm.273024