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  4. Recombinant Mouse Thyrotropin receptor (Tshr), partial

Recombinant Mouse Thyrotropin receptor (Tshr), partial

  • 货号：
    CSB-MP025131MO
  • 规格：
    ￥3960
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tshr; Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 来源：
    Mammalian cell
  • 分子量：
    46.9
  • 表达区域：
    22-413aa
  • 氨基酸序列
    KECASPPCECHQEDDFRVTCKELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTAIDNDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNILRGPIYQEYEEDPGDNSVGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFGQELKNPQEETLQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
  • 基因功能参考文献：
    1. Data suggest that stimulation of Tsh/Tshr signaling increases apoptosis and suppresses autophagy in primary chondrocytes. PMID: 28626114
    2. Unlike its critical role in maintaining the normal growth and function of the thyroid gland, our results demonstrated that hepatic TSHR is involved in liver lipid metabolism and has little effect on energy metabolism. PMID: 29421660
    3. Data indicate that splenic T cells from thyroid stimulating hormone receptor (TSHR) A-subunit primed animals undergoing Graves' orbitopathy (GO) showed proliferative responses to purified TSHR antigen and secreted proinflammatory cytokines. PMID: 26872090
    4. Lung fibroblasts of TSHR KO mice have decreased cell surface Igf1r expression, and have Igf1r protein and protein fragments in both cytoplasm and nucleus. Igf1r mRNA levels were similar between TSHR KO and WT mice. PMID: 26389690
    5. The mechanism, underlying TSH-induced liver triglyceride accumulation, involved that TSH, through its receptor TSHR, triggered hepatic SREBP-1c activity. PMID: 25016220
    6. These findings suggest that activation of TSHR directly inhibits FASN expression in mature adipocytes, possibly mediated by PKA and ERK PMID: 25655684
    7. A novel role for TSHR in behavioral and neurological phenotypes of Attention deficit/hyperactivity disorder. PMID: 25016105
    8. The data indicate functional TSHR is expressed in ventricular myocytes and mediates TSH-induced BNP secretion and HMGCR up-regulation through the cAMP/PKA/pCREB signaling pathway. PMID: 24065308
    9. findings demonstrate TSH-R expression is thymus-specific within the immune system; data support the notion of a novel neuroendocrine-immune interaction in which TSH-R signaling in the thymus, most likely mediated by TSH, enhances thymic T-cell development PMID: 24635198
    10. The inhibition of hepatic PEPCK and G6P and enhanced expression of GK contributed to the development of fasting hypoglycemia in Tshr-ko mice. PMID: 23665701
    11. UCP-1 and TSHR co-localized in retrobulbar adipose tissues in murine models of Graves' disease. PMID: 23386414
    12. Cloned a thyroid-stimulating hormone receptor (TSHR) cDNA from thyroid glands. The sequence of this cDNA indicated that it encoded a 739 amino acid TSHR splice variant that lacked exon 5 (TSHR739). PMID: 23538203
    13. Study with mouse monoclonal antibody 3BD10 confirms TSHR conformational heterogeneity and suggests that the N-terminal cysteine cluster may contribute to this structural variability. PMID: 23183178
    14. Messenger RNA levels of hormone-sensitive lipase in epididymal fat containing the transferred TSHR gene were twofold higher than those in tissue from the control side PMID: 22496347
    15. Data demonstrate the key role of TSH signaling in Braf-induced papillary thyroid cancer initiation and provide experimental support for observations in humans pointing to a strong association between TSH levels and thyroid cancer incidence. PMID: 21220306
    16. Studies indicate it is important to refine knowledge and insights in non-autoimmune diseases caused by defects of the TSHR gene and it might help to develop pharmacological means for compensation of uncontrolled thyroid growth. PMID: 20515734
    17. TSHR KO mice are, therefore, of value for future studies dissecting the autoimmune response to the mouse TSHR. PMID: 20555026
    18. adipocyte TSHr under normal conditions affects adipocyte growth and development. PMID: 20152797
    19. Consequences of hypothyroidism on auditory system function in Tshr mutant (hyt) mice. PMID: 11833606
    20. Development of auditory brainstem responses (ABRs) in Tshr mutant mice derived from euthyroid and hypothyroid dams. PMID: 11833607
    21. Knockout mice were used to study the role of the TSHR signaling in thyroid development & differentiation. The major role of the TSH/TSHR pathway is controlling genes involved in iodide metabolism. PMID: 12432093
    22. TSHR expression was required for expression of sodium-iodide symporter but was not required for thyroglobulin expression, suggesting that the thyroid hormone synthetic pathway of the mouse could be dissociated into TSHR-dependent and -independent steps. PMID: 12432094
    23. TSHR action is complemented by RII-PKAII which stably propagates robust cAMP signals in cell compartments PMID: 12902333
    24. Ttf1 haploinsufficiency causes a reduction in the expression of TSHr and thyroglobulin, genes with TTF1 binding sites in their promoter regions PMID: 12907760
    25. Pituitary folliculo-stellate cells express functional TSHR not coupled to cAMP nor IP3 but probably signals through JAK/STAT5a pathway. In vitro model to study role of TSHR in pituitary folliculo-stellate cells PMID: 15662590
    26. Higher somatic mutations within complementarity-determining region 3 may correlate with pathogenic antibodies against TSH receptor. PMID: 17068139
    27. Tshr(-/-) mice produced normal numbers of cones, indicating that the major requirement for thyroid hormone is in opsin patterning rather than in cone generation. PMID: 18974269
    28. Melatonin activates Tshr expression in the pars tuberalis but not in the ependymal cell layer of the infundibular recess. PMID: 19589858

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  • 相关疾病：
    Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH.
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 数据库链接：

    KEGG: mmu:22095

    STRING: 10090.ENSMUSP00000021346

    UniGene: Mm.173847