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  4. Recombinant Mouse Thymosin beta-4 (Tmsb4x)

Recombinant Mouse Thymosin beta-4 (Tmsb4x)

  • 货号：
    CSB-YP023934MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023934MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023934MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023934MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023934MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tmsb4x; Ptmb4; Tmsb4; Thymosin beta-4; T beta 4) [Cleaved into: Hematopoietic system regulatory peptide; Seraspenide)]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    1-50
  • 氨基酸序列
    MLLPATMSDK PDMAEIEKFD KSKLKKTETQ EKNPLPSKET IEQEKQAGES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
  • 基因功能参考文献：
    1. Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down. PMID: 29864422
    2. expressed prominently in podocytes; modifier of glomerular injury PMID: 27575556
    3. Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle. PMID: 27914791
    4. Increased Tb4 expression was observed in ethanol treated microglia. Knockdown of Tb4 enhanced ethanol-induced inflammatory mediators tumor necrosis factor-alpha and interleukin-1beta and nitric oxide in BV-2 cells was performed. PMID: 27189760
    5. Results provide evidence that Tbeta4 regulate the levels of VEGF and MMP-2 via the Wnt/beta-catenin/Lef-1 signaling pathway to influence the growth of blood vessels around hair follicles and to activate cell migration. PMID: 27130465
    6. we identified the C-terminal four amino-acid variable end of TB4 as the essential and responsible domain for the molecule's full benefits in the hypoxic heart. PMID: 26255251
    7. From the results, Tbeta4 increased the viability and promoted the differentiation and mineralization of MC3T3-E1 cells on Ti discs. PMID: 27433712
    8. this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro. PMID: 26789270
    9. this study demonstrates, for the first time, that Tbeta4 is expressed in developing periodontal tissue and that its expression is associated with osteoblastic/cementoblastic differentiation. PMID: 26361868
    10. Tbeta4 appears to regulate P38/ERK/AKT signaling via its effect on VEGF expression, with a resultant effect on the speed of hair growth, the pattern of HFs and the number of hair shafts PMID: 26083021
    11. This study provides putative information concerning the signaling pathway through which Tb4 induces RUNX2 expression, which may help to understand the regulation of tooth development and tooth regeneration. PMID: 25739055
    12. Tbeta4 substantially inhibited bleomycin-induced IL-17 over-expression in the lung tissue: a decreased amount of IL17-producing cells and inhibited IL-17 expression in lung with Tbeta4 treatment correlate with its anti-inflammatory and anti-fibrotic effects. PMID: 24613476
    13. The results suggest that Tbeta4 plays multiple functional roles in odontogenic epithelial cells in the early stages of tooth germ development by regulating the expression of odontogenesis-related genes. PMID: 23052839
    14. Analysis at 21 days post-fracture show that the fractional volume of new mineralized tissue and new highly mineralized tissue are greater in calluses from Tbeta4-treated mice compared to controls. PMID: 25042765
    15. These data suggest that Tbeta4 suppresses the TLR proinflammatory pathway by up-regulating miR-146a. PMID: 24828499
    16. Demonstrate that Tbeta4 is dispensable for embryonic viability and vascular development. PMID: 23371905
    17. Thymosin beta4 may play a role in aging-related hearing loss. PMID: 15813012
    18. These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. PMID: 22305657
    19. Thymosin beta4 is a novel endothelial secreted trophic factor that functions synergistically with TGFbeta to regulate mural cell development and vascular wall stability. PMID: 22723298
    20. The results suggest that Tb4 may be involved in oral epithelial cell proliferation at the initial stage of tooth development and regulates the expression and secretion of proteins during odontoblast differentiation. PMID: 22344518
    21. Tbeta4 may influence the remodeling of collicular neuronal processes, possibly in the context of a re-alignment of the sensory and motor maps in the deep superior colliculus after monocular deprivation. PMID: 21626305
    22. Tbeta4 is dispensable for embryonic viability, heart development, coronary vessel development, and adult myocardial function. PMID: 22158707
    23. results suggest that in Trichinella spiralis infection, the expression of VEGF and thymosin beta4 induce angiogenesis and the expression of thymosin beta4 remained elevated to potentially regulate nurse cell formation and maintenance PMID: 21531510
    24. In a mouse model of multiple myeloma thymosin beta4 overexpression leads to significantly decreased proliferative and migratory capacity and increased sensitivity to apoptosis induction. PMID: 19833631
    25. Hand1-mediated activation of Tbeta4 is essential for yolk sac vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac capillary plexus formation in Hand1-null embryos. PMID: 20975697
    26. Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration. PMID: 19861493
    27. Data show that in mouse tissues, thymosin beta4 is associated with microglia and macrophages. PMID: 19631707
    28. Up-regulation of Tb4 gene expression may be responsible for the disintegration of the musculature during the development of adenomyosis PMID: 14758721
    29. thymosin beta4 promotes cardiomyocyte migration, survival and repair PMID: 15565145
    30. Promoter and silencer were found in the first exon of the thymosin beta 4 gene. PMID: 16010974
    31. thymosin beta4 (Tbeta4) as essential for all aspects of coronary vessel development in mice PMID: 17108969
    32. mediator of progenitor cell -mediated cardioprotection in myocardial reperfusion injury PMID: 18427126

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Thymosin beta family
  • 组织特异性：
    Originally found in thymus but it is widely distributed in many tissues.
  • 数据库链接：

    KEGG: mmu:19241

    STRING: 10090.ENSMUSP00000107795

    UniGene: Mm.142729