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  4. Recombinant Mouse TRAF-interacting protein (Traip)

Recombinant Mouse TRAF-interacting protein (Traip)

  • 中文名称：
    小鼠Traip重组蛋白
  • 货号：
    CSB-YP845041MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Traip重组蛋白
  • 货号：
    CSB-EP845041MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Traip重组蛋白
  • 货号：
    CSB-EP845041MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Traip重组蛋白
  • 货号：
    CSB-BP845041MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Traip重组蛋白
  • 货号：
    CSB-MP845041MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Traip
  • Uniprot No.：
  • 别名：
    Traip; Trip; E3 ubiquitin-protein ligase TRAIP; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRAIP; TRAF-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-470
  • 氨基酸序列
    MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKKTIIN KLFFDLAQEE ENVLDAEFLK NELDSVKAQL SQKDREKRDS QAIIDTLRDT LEERNATVES LQNALNKAEM LCSTLKKQMK FLEQRQDETK QAREEAHRLK CKMKTMEQIE LLLQSQRSEV EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKATGE LADRLKKDLV SSRSKLKTLN TELDQAKLEL RSAQKDLQSA DQEITSLRKK LMILQGTLSL PPATNETVSR LVFESPAPVE MMNPRLHQPP FGDEIDLNTT FDVNTPPTQT SGSQHCLPKK LCLERARSPM QNVLKKVHKV SKPESQLSLG GQRCVGELDE ELAGAFPLFI RNAVLGQKQP NRTTAESRCS TDVVRIGFDG LGGRTKFIQP RDTTIIRPVP VKSKAKSKQK VRIKTVSSAS QPKLDTFLCQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway. Only catalyzes ubiquitination of MCM7 when forks converge. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome. Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity. The function in translesion synthesis is however controversial. Acts as a regulator of the spindle assembly checkpoint. Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation.
  • 基因功能参考文献：
    1. Taken together, these data indicate that TRAIP plays important roles in oocyte meiosis regulation. PMID: 27405720
    2. TRIP as a negative regulator in TLR3/4- and RIG-I-triggered antiviral responses and suggested TRIP as a potential target for the intervention of diseases with uncontrolled IFN-beta production. PMID: 22945920
    3. TRIP is an essential factor during early mouse embryonic development in vivo PMID: 17927961
  • 亚细胞定位：
    Nucleus, nucleoplasm. Nucleus, nucleolus. Chromosome. Cytoplasm. Cytoplasm, perinuclear region.
  • 组织特异性：
    Detected in testis and thymus, and at lower levels in spleen.
  • 数据库链接：

    KEGG: mmu:22036

    STRING: 10090.ENSMUSP00000040001

    UniGene: Mm.297870