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  4. Recombinant Mouse THAP domain-containing protein 11 (Thap11)

Recombinant Mouse THAP domain-containing protein 11 (Thap11)

  • 中文名称：
    小鼠Thap11重组蛋白
  • 货号：
    CSB-YP862379MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Thap11重组蛋白
  • 货号：
    CSB-EP862379MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Thap11重组蛋白
  • 货号：
    CSB-EP862379MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Thap11重组蛋白
  • 货号：
    CSB-BP862379MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Thap11重组蛋白
  • 货号：
    CSB-MP862379MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Thap11
  • Uniprot No.：
  • 别名：
    Thap11; MNCb-2032; THAP domain-containing protein 11; Ronin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-305
  • 氨基酸序列
    MPGFTCCVPG CYNNSHRDKA LHFYTFPKDA ELRRLWLKNV SRAGVSGCFS TFQPTTGHRL CSVHFQGGRK TYTVRVPTIF PLRGVNERKV ARRPAGAAAA RRRQQQQQQQ QQQQQQQQLQ QQQPSPSSST AQTTQLQPNL VSASAAVLLT LQAAVDSNQA PGSVVPVSTT PSGDDVKPID LTVQVEFAAA EGAAAAAAAS ELEAATAGLE AAECTLGPQL VVVGEEGFPD TGSDHSYSLS SGTTEEELLR KLNEQRDILA LMEVKMKEMK GSIRHLRLTE AKLREELREK DRLLAMAVIR KKHGM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers.
  • 基因功能参考文献：
    1. The activity of Ronin coincided with the recruitment of its cofactor, Hcf-1, and the elevation of H3K4me3 levels at specific target genes, suggesting the involvement of an epigenetic mechanism. PMID: 29117561
    2. Ronin binds to and regulates the genes encoding several DNA repair factors, including Gtf2h4 and Rad18, providing a potential mechanism for this phenotype. PMID: 28715716
    3. Ronin is a positive regulator of mitochondrial gene expression that coordinates mitochondrial activity and cell cycle progression in the developing retina. PMID: 26876175
    4. Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells. PMID: 20581084
    5. Findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency; its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells. PMID: 18585351

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus.
  • 蛋白家族：
    THAP11 family
  • 组织特异性：
    Mainly restricted to pluripotent cells of the developing embryo, to oocytes, and to certain regions of the adult brain.
  • 数据库链接：

    KEGG: mmu:59016

    STRING: 10090.ENSMUSP00000048994

    UniGene: Mm.286598