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  4. Recombinant Mouse TGF-beta receptor type-2 (Tgfbr2), partial

Recombinant Mouse TGF-beta receptor type-2 (Tgfbr2), partial

  • 中文名称：
    小鼠Tgfbr2重组蛋白
  • 货号：
    CSB-YP720297MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tgfbr2重组蛋白
  • 货号：
    CSB-EP720297MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tgfbr2重组蛋白
  • 货号：
    CSB-EP720297MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tgfbr2重组蛋白
  • 货号：
    CSB-BP720297MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tgfbr2重组蛋白
  • 货号：
    CSB-MP720297MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tgfbr2; TGF-beta receptor type-2; TGFR-2; EC 2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
  • 基因功能参考文献：
    1. the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis PMID: 29352019
    2. altered Tgfbeta signaling in cultured mouse and human enteroids supports further the in vivo data and reveals a critical role for Tgfbeta signaling in generating precursor secretory cells. Overall, our data reveal a key role for Tgfbeta signaling in regulating ISCs clonal dynamics and differentiation, with implications for cancer, tissue regeneration, and inflammation. PMID: 27791005
    3. In young Fbn1(C1039G/+) mice, aortopathy develops in the absence of detectable alterations in smooth muscle cell (SMC) TGF-beta signaling. Loss of physiologic SMC TGF-beta signaling exacerbates MFS-associated aortopathy. Our data support a protective role for SMC TGF-beta signaling during early development of MFS-associated aortopathy. PMID: 28119285
    4. The present study demonstrates that TGFbeta responsiveness in the myeloid compartment is critical in controlling autoimmune encephalomyelitis, and that its specific deletion in monocyte-derived dendritic cells causes severe experimental autoimmune encephalomyelitis without remission. PMID: 27479807
    5. These results suggest proliferation and maturation of immature osteoblasts requires Tgfbr2 signaling and that decreased bone volume in Osx-Cre;Tgfbr2(fl/fl) mice is likely due to fewer mature osteoblasts. PMID: 28043895
    6. The s identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma. PMID: 28219480
    7. Cell-intrinsic TGFbeta-RII signaling limits CD4 T cell proliferation but not prototypical T helper subset differentiation early after chronic lymphocytic choriomeningitis virus infection. PMID: 27599295
    8. Knockout of the TGFbeta receptor in proopiomelanocortin neurons counteracts the hypertensive effect of not only TGFbeta but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGFbeta receptor antagonist or genetically by TGFbeta receptor knockout. PMID: 27894066
    9. Postnatal disruption of Tgfbr2 gene compromises extracellular matrix properties and promotes aortic dissection, which can be prevented by rapamycin treatment. PMID: 26988590
    10. Gasdermin C is upregulated by inactivation of Tgfbr2 in the presence of mutated Apc, promoting colorectal cancer cell proliferation. PMID: 27835699
    11. Epithelial TGFbeta signaling via TGFBR2 does not contribute to the development of liver fibrosis or formation of hepatocellular carcinomas in mice, but restricts cholangiocyte proliferation to prevent cholangiocarcinoma development. PMID: 26627606
    12. The removal of Tgfbr2 and treatment with losartan both delayed the progression of articular cartilage degeneration induced by medial meniscus (DMM) compared with control littermates. PMID: 26355014
    13. Data (including data from studies in transgenic mice) suggest intraislet pancreatic duct cells are capable of giving rise to insulin-secreting beta-cells; Tgfbr2/transforming growth factor-beta type II receptor appears to be involved in this process. PMID: 26505114
    14. Elimination of TGF-betaIIR is not sufficient to completely prevent liver fibrosis. TGF-beta-independent mechanism of type I collagen production and suggest connective tissue growth factor as its potent mediator. PMID: 25108224
    15. Overexpression of TGFbeta1 promotes pulmonary inflammation, apoptosis and mortality via TGFbetaR2 in the developing mouse lung. PMID: 25591994
    16. Loss of smooth muscle cells Tgfbr2 disrupts TGF-beta signaling, acutely alters SMC gene expression, and rapidly results in severe and durable aortopathy. PMID: 26494233
    17. Increased Tgfbr2 expression is associated with pulmonary fibrosis. PMID: 26216407
    18. Suggest that miR-370 acting via TbetaRII might play a potential role in hepatic IR injury, and inhibition of miR-370 efficiently attenuated the damage to the liver. PMID: 24351048
    19. skeletal phenotype of mice carrying a mutation in the TGF-beta type 2 receptor associated with severe Loeys-Dietz syndrome in humans: Cortical bone showed significantly reduced tissue area, bone area, and cortical thickness with increased eccentricity PMID: 26173585
    20. Expression of microRNA-211 is regulated by the key melanocyte transcription factor MITF and regulates pigmentation by targeting the TGF-beta receptor 2. PMID: 25444235
    21. TGFBR2-dependent molecular crosstalk between neural and endothelial cells during brain vessel development was discovered. PMID: 24990151
    22. TGF-beta signaling plays an important role in dentin formation and pulp protection. Furthermore, our findings may provide new insight into possible mechanisms underlying human hereditary dentin disorders and reparative dentin formation. PMID: 25818583
    23. taken together, indicate that a simple genetic alteration in the TGFbeta signaling pathway in the inflamed and regenerating intestinal mucosa can cause invasive intestinal tumors. PMID: 25687406
    24. phosphorylation of tyrosines within the TbetaRII tail was essential for SMAD-dependent fibrotic signaling within cells of the kidney collecting duct PMID: 24983314
    25. Conditional deletion of Tgfbr2 in keratin 14-positive stratified epithelia causes ocular surface epithelial hyperplasia and conjunctival goblet cell expansion that invaginates into the subconjunctival stroma in the mouse eye. PMID: 25377551
    26. The TGFbetaRII-mediated signaling in thymic epithelial cells inhibits their development into Hassall's corpuscles in mice PMID: 23929912
    27. CD4Foxp3 thymocytes from mice with the Tgfbr2 deletion expressed high levels of CXCR3. PMID: 24165986
    28. basal TGF-beta signaling in smooth muscle promotes postnatal aortic wall homeostasis and impedes disease progression PMID: 24401272
    29. TGFbeta regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. PMID: 24496627
    30. Inhibition of TGFbeta signaling (deletion of the Tgfbr2 gene in chondrocytes) resulted in up-regulation of Runx2, Mmp13, and Adamts5 expression in articular cartilage tissue and progressive osteoarthritis development in TGFbetaRII(Col2ER) mice. PMID: 23982761
    31. Data indicate thate TGFbeta activates the ABL1 pathway in the absnce of TGFbeta receptor type II (TbetaRII) during tongue development. PMID: 23950180
    32. Osx-Cre;Tgfbr2(fl/fl) mice were generated (Tgfbr2(cko)) and post-natal tooth development was compared in Tgfbr2(cko) and control littermates. PMID: 23933490
    33. Spatial and temporal expression of Tgfbr2 is regulated during mouse forelimb development. PMID: 23231014
    34. TbetaRII-deficient mice showed a lower level of developmental apoptosis of retinal neurons. PMID: 23986258
    35. Reduced cholesterol synthesis is observed in Tgfbr2 mutant palatal tissue. PMID: 23060211
    36. This study uncovers a previously unrecognized dominant function of the dnTGFbetaRII in CD8(+) T cell proliferation and cellular transformation PMID: 23686479
    37. Increased copy number of dnTGFbetaRII is critical for development of lymphoma-like T cell infiltration. PMID: 23145171
    38. gross alterations in dorsal vertebrae were apparent by E16.5days in Tgfbr2 mutants PMID: 22369999
    39. Loss of Tgfbr2 in hypertrophic chondrocytes using Col10a1-Cre mice resulted in delays in both the hypertrophic conversion of proliferating chondrocytes and terminal chondrocyte differentiation PMID: 22885149
    40. IRF6 and SMAD4 synergistically regulate the fate of the medial edge epithelium(MEE), and TGFbeta-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice. PMID: 23406900
    41. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567. PMID: 23290524
    42. Deficiency of the TGF-beta type II receptor protected proximal tubule epithelial cells from apoptosis. PMID: 23160515
    43. TGFbetaR2 signaling in dendritic cells is critical to control autoimmunity through both regulatory T (Treg) cell-dependent and -independent mechanisms. PMID: 22972928
    44. TGFbeta signalling is essential in vascular endothelial cells for maintaining vascular integrity at the angiogenic front as it migrates into developing neural tissues in early postnatal life. PMID: 22745736
    45. Results establish a novel role for TGFbeta signaling in expression of genes for alternatively activated macrophages. Lack of TbetaRII signaling may reduce the anti-inflammatory M2 phenotype of macrophages because of reduced expression of these products. PMID: 22703233
    46. Treatment of PyMT/Tgfbr2(KO) mice with anti-IL-17 Ab decreased carcinoma growth and metastatic burden. PMID: 22408746
    47. We conclude that Tgfbr2 in myeloid cells has a negative role in the regulation of anti-tumorigenic functions of these cells PMID: 22685318
    48. The TbetaRII/monocyte-chemoattractant protein (MCP)-5 axis is an essential crossroad for joint development and endochondral growth. PMID: 22814601
    49. TbetaRII may determine the distinct roles of TGF-beta1 in inflammation and fibrogenesis in a mouse model of ureteral obstruction induced nephropathy. PMID: 22190171
    50. Data show that dual Dicer-deficient and TGFbetaRII-deficient mice show defects in both TGFbeta-mediated tolerance and miR production. PMID: 22225602

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 组织特异性：
    Widely expressed in adult. Expressed primarily in mesenchyme and epidermis of the midgestational fetus.
  • 数据库链接：

    KEGG: mmu:21813

    STRING: 10090.ENSMUSP00000062333

    UniGene: Mm.172346