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  4. Recombinant Mouse TCDD-inducible poly [ADP-ribose] polymerase (Tiparp)

Recombinant Mouse TCDD-inducible poly [ADP-ribose] polymerase (Tiparp)

  • 货号：
    CSB-YP806010MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806010MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806010MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806010MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806010MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tiparp
  • Uniprot No.：
  • 别名：
    TiparpProtein mono-ADP-ribosyltransferase TIPARP; EC 2.4.2.-; ADP-ribosyltransferase diphtheria toxin-like 14; ARTD14; TCDD-inducible poly [ADP-ribose] polymerase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-657
  • 氨基酸序列
    MEVETTEPEP DCVVQPPSPS DDFSCQMRIS EKISPLKTCF KKKQEQKRLG TGTLRSLRPI LNTLLESGSL DGVFRARDQN RDESSLHEHI VKKPLEINPS CPPAENSMPV LIPDGTNVEG QLPEAHPSTD APEQGVPIQD HSFPPETISG TVADSTTGHF QTDLLHPVSG DVPTSPDCVD KVMDYVPGAF QDNSFTIQYI LDTSDKLSTE LFQDKSEEAS LELVFELVNQ LQYHTHQENG IEICMDFLQG TCIYGRDCLK HHTVLPYHWQ IKRTTTQKWQ SVSNDSQEHL ERFYCNPEND RMRMKYGGQD FWADLNAMTV FETTEFDQLR RLSTPPCSNS NSIYHTFWKF FCRDHFGWRE YPESVVRLIE EANSRGLKEV RFMMWNNHYI LHNSFFRREI KRRPLFRSCF ILIPYLQTLG GVPTQASLPL EATSSQIICP DGVTSANFYP ETWVYMHPSQ DFIQVPVSAE DKSYRIIYNL FHKTVPEFKY RILQILRVQN QFLWEKYKRK KEYMNRKMSG RDRIINERHL FHGTSQDVVD GICKHNFDPR VCGKHATMFG QGSYFAKKAS YSHNFSKKSS KGVHFMFLAK VLTGRYTMGS HGMRRPPPVN PGSVTSDLYD SCVDNFFEPQ IFVIFNDDQS YPYFVIQYEE VSNTVSI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable).
  • 基因功能参考文献：
    1. this study shows that aryl hydrocarbon receptor upregulates expression of TIPARP, which in turn causes downregulation of the IFN type I response PMID: 27089381
    2. these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1. PMID: 26814197
    3. Loss of Tiparp increases sensitivity to dioxin toxicity and lethality. PMID: 25975270
    4. Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels. PMID: 24806346
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: mmu:99929

    STRING: 10090.ENSMUSP00000048051

    UniGene: Mm.246398