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  4. Recombinant Mouse TBC1 domain family member 23 (Tbc1d23)

Recombinant Mouse TBC1 domain family member 23 (Tbc1d23)

  • 中文名称：
    小鼠Tbc1d23重组蛋白
  • 货号：
    CSB-YP815638MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Tbc1d23重组蛋白
  • 货号：
    CSB-EP815638MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Tbc1d23重组蛋白
  • 货号：
    CSB-EP815638MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Tbc1d23重组蛋白
  • 货号：
    CSB-BP815638MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Tbc1d23重组蛋白
  • 货号：
    CSB-MP815638MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tbc1d23
  • Uniprot No.：
  • 别名：
    Tbc1d23; TBC1 domain family member 23
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-684
  • 氨基酸序列
    MAEGEELLPL STSGGDSWEK DLEEALEAGG CDLETLRNII QGRPLPAELR AKVWKIALNV AGKGDSLASW DGILDLPEQN TIHKDCLEFI EQLSVPEEKA AELLLDIESV ITFYCKSRSV KYSTSLSWIH LLKPLICLQL PRSDLYNCFY AVMNKYIPRD CSLKGRPFHL FRLLIQYHEP ELCSFLDTKK ITPDSYALNW LGSLFAHYCS TEVTQAIWDG YLQQADPFFI YFLMLIILVN TKEVILAQES DSKEEVIRFL ESTPASLNLE DIEDLFSLAQ YYCSKTPASF RKDNHHLFGS TLLGIKDDEA DLSQALCLAV SVSEILQANQ LQGEGVRFFV VDCRPAEQYN AGHLATAFHL DSDLMLQNPS EFAQSVKSLL EAQKQSIESG SIAGGEHLCF MGSGREEEDM YMNMVLAHFL QKNKEYVSIA SGGFMALQQH LADINVEGPE SGYGHWIAST SGSRGSISSV DGESCNGSND RGMKSLVSKM TVALKTKSVT VREKVISFIE NSSTPVDRHV SSSDRVGKPY RGVKPVFSIG DEEEYDTDEI DSSSMSDDDR KEVVNIQTWI NKPDIKHHFP CKEVKESGHM FPSHLLVTAT HMYCLREILS RKGLAYIQSR QALNSVVKIT SKKKHPELIT FKYGNSSASG IEILAIERYL IPNAGDATRA IKQQIMKVLD ALES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge.
  • 基因功能参考文献：
    1. Homozygous Truncating Variants in TBC1D23 gene are associated with Pontocerebellar Hypoplasia and Alter Cortical Development. PMID: 28823707
    2. we now show that Tbc1d23 is a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin-signaling pathways PMID: 22312129
  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle.
  • 数据库链接：

    KEGG: mmu:67581

    STRING: 10090.ENSMUSP00000023431

    UniGene: Mm.257819