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  4. Recombinant Mouse Synapsin-2 (Syn2)

Recombinant Mouse Synapsin-2 (Syn2)

  • 货号：
    CSB-YP734098MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP734098MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP734098MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP734098MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP734098MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Syn2
  • Uniprot No.：
  • 别名：
    Syn2; Synapsin-2; Synapsin II
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-586
  • 氨基酸序列
    MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQPPPAPGP GAATASAATS AASPGPERRP PPAQAPAPQP APQPAPTPSV GSSFFSSLSQ AVKQTAASAG LVDAPAPSAA SRKAKVLLVV DEPHTDWAKC FRGKKILGDY DIKVEQAEFS ELNLVAHADG TYAVDMQVLR NGTKVVRSFR PDFVLIRQHA FGMAENEDFR HLVIGMQYAG LPSINSLESI YNFCDKPWVF AQMVAIFKTL GGEKFPLIEQ TYYPNHREML TLPTFPVVVK IGHAHSGMGK VKVENHYDFQ DIASVVALTQ TYATAEPFID AKYDIRVQKI GNNYKAYMRT SISGNWKTNT GSAMLEQIAM SDRYKLWVDA CSEMFGGLDI CAVKAVHGKD GKDYIFEVMD CSMPLIGEHQ VEDRQLITDL VISKMNQLLS RTPALSPQRP LTTQQPQSGT LKEPDSSKTP PQRPPPQGGP GQPQGMQPPG KVLPPRRLPS GPSLPSSSSS SSSSSSSSSA PQRPGGPTTT HGDASSSSNS LAEAQAPQAA PAQKPQPHPQ LNKSQSLTNA FSFSESSFFR SSANEDEAKA ETIRSLRKSF ASLFSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.
  • 基因功能参考文献：
    1. results reveal a permissive contribution of Syn2 to the expression of normal socio-communicative behavior PMID: 28922833
    2. These results reveal a new SynII function in the regulation of the time course of GABA release and demonstrate that this function is dependent on the interneuron subtype. PMID: 28087765
    3. This study demonstrated that synapsin 2 regulating GABA Release from Hippocampal Interneurons. PMID: 27335405
    4. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to Gbetagamma-PLCbeta3-ERK1/2-synapsin 2 PMID: 22673524
    5. Deletion of synapsin II, a presynaptic protein contributing to epilepsy predisposition in humans, leads to a loss of tonic inhibition in mouse hippocampal slices due to a dramatic decrease in presynaptic asynchronous GABA release. PMID: 24962993
    6. In synapsin II(-) hippocampal neurons an overexcitable phenotype was observed. PMID: 24227741
    7. Behavioral and neurophysiological features of Syn-2 knockout mice are characterized by observation of the development and progress of seizures from postnatal day 20 to 180. PMID: 22846639
    8. The histone modification marks were significantly increased in bipolar disorder and major depression and this effect was correlated with significant increases in syn2 gene expression. PMID: 22571925
    9. Syn II promotes gamma-aminobutyric acid asynchronous release in a Ca(2+)-dependent manner. PMID: 23443540
    10. Taken together, our results suggest that synapsin II and Rab3a have separate roles in maintaining the total store of synaptic vesicles and cooperate in promoting the latest steps of neuronal secretion. PMID: 20338242
    11. study provided high sequence coverage information on synapsin 2a and 2b in mouse and rat, revealing highest identity between the species; phosphorylation sites were determined PMID: 19609639
    12. Results indicate that a cAMP/PKA-dependent mechanism involving the AP-2alpha transcription factor is likely responsible for the increase in neuronal synapsin II following dopamine D1 receptor stimulation or dopamine D2 receptor inhibition. PMID: 19842069
    13. synapsin II can regulate vesicle clustering, transmitter release, and facilitation. PMID: 15388780
    14. Synapsin II knockout mice show sensorimotor gating and behavioural abnormalities similar to those in the phencyclidine-induced preclinical animal model of schizophrenia. PMID: 17900867
    15. We conclude that synapsin IIa serves as a negative regulator of catecholamine release and that this protein influences exocytosis from a readily releasable pool of chromaffin granules. PMID: 17957479
    16. While both synaptic vesicle number and presynaptic plasticity are independent of synapsin II prior to postnatal day 10, maturation and function of excitatory synapses are dependent on synapsin II from postnatal day 20. PMID: 18606212
    17. Microinjection of a recombinant synapsin II protein into synapsin II (-) terminals reduced vesicular docking and inhibited quantal release. PMID: 18669537
    18. synapsin II is involved in the regulation of glutamate and GABA release in the spinal cord after nerve injury. PMID: 18701217
    19. synapsins define the kinetics of synaptic depression at glutamatergic synapses by controlling the size of the vesicular reserve pool and identify synapsin IIa as the isoform primarily responsible for this task. PMID: 18945891
    20. These results confirm that synapsin II knockout mice display behavioral endophenotypes similar to established preclinical animal models of schizophrenia. PMID: 19360855

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  • 亚细胞定位：
    Cell junction, synapse.
  • 蛋白家族：
    Synapsin family
  • 组织特异性：
    Expressed exclusively in neuronal cells. Isoform IIb is enriched in sympathetic cervical ganglion.
  • 数据库链接：

    KEGG: mmu:20965

    STRING: 10090.ENSMUSP00000009538

    UniGene: Mm.441431