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  4. Recombinant Mouse Switch-associated protein 70 (Swap70)

Recombinant Mouse Switch-associated protein 70 (Swap70)

  • 中文名称：
    小鼠Swap70重组蛋白
  • 货号：
    CSB-YP737992MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Swap70重组蛋白
  • 货号：
    CSB-EP737992MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Swap70重组蛋白
  • 货号：
    CSB-EP737992MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Swap70重组蛋白
  • 货号：
    CSB-BP737992MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Swap70重组蛋白
  • 货号：
    CSB-MP737992MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Swap70
  • Uniprot No.：
  • 别名：
    Swap70; Kiaa0640; Switch-associated protein 70; SWAP-70
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-585
  • 氨基酸序列
    MRGLKDELLK AIWHAFTALD LDRSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD EGPVSNQGYM PYLNKFILEK VQDNFDKIEF NRMCWTLCVK KNLTKSPLLI TEDDAFKVWV IFNFLSEDKY PLIIVPEEIE YLLKKLTEAM GGGWQQEQFE HYKINFDDNK DGLSAWELIE LIGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMMKK GHKRKNWTER WFVLKPNIIS YYVSEDLKDK KGDILLDENC CVESLPDKDG KKCLFLIKCF DKTFEISASD KKKKQEWIQA IYSTIHLLKL GSPPPHKEAR QRRKELRRKL LAEQEELERQ MKELQAANEN KQQELESVRK KLEEAASRAA DEEKKRLQTQ VELQTRFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQAIQTTEA EKQELEQQRV MKEQALQEAM AQLEQLELER KQALEQYEGV KKKLEMATHM TKSWKDKVAH HEGLIRLIEP GSKNPHLITN WGPAAFTQAE LEEREKSWKE KKTTE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 基因功能参考文献：
    1. Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs). PMID: 28780965
    2. findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides PMID: 28468968
    3. DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology PMID: 27561029
    4. SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts. PMID: 26103139
    5. These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks. PMID: 23921380
    6. Cells expressing the mutant SWAP-70 exhibited faster growth than the parental or wild-type SWAP-70-expressing cells underscoring its role in neoplastic transformation. PMID: 23555004
    7. SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells. PMID: 23544157
    8. SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs. PMID: 23636062
    9. A novel function of the F-actin binding and regulatory protein SWAP-70 in osteoclast biology, is reported. PMID: 22648978
    10. regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure. PMID: 22210919
    11. SWAP-70 regulates erythropoiesis by controlling alpha4 integrin. PMID: 21880631
    12. in a dose-dependent manner, SWAP-70 controls IRF-4 protein expression and thereby regulates the initiation of plasma cell differentiation PMID: 21728176
    13. SWAP-70-374 can activate some signaling pathways, including the ERK1/2 pathway, to transform MEFs PMID: 21152038
    14. These data demonstrate SWAP-70 as a novel regulator of S1P signaling necessary for dendritic cell motility and endocytosis. PMID: 21421853
    15. regulator of the cell adhesion and B-cell differentiation PMID: 21108474
    16. In mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells. PMID: 11920580
    17. SWAP-70 is an important regulator of specific effector pathways in c-kit signaling, including mast cell activation, migration, and cell adhesion PMID: 15542837
    18. These data identify SWAP-70 as a transient component of early macropinosomes. PMID: 17046101
    19. SWAP-70 deficiency uncouples germinal center formation from T-dependent antibody and long-lived plasma cell production and causes extrafollicular generation of high-affinity plasma cells, but does not adequately support the memory response. PMID: 18094331
    20. SWAP-70 defines a new element of efficient mast cell activation upon FcepsilonRI signaling, important for the control of mast cell-dependent anaphylaxis. PMID: 18236401
    21. results suggest that v-Src and SWAP-70 act synergistically in the invasion activity of mouse embryo fibroblasts PMID: 18344189
    22. Through RhoA/RhoB regulation, SWAP-70 defines a new pathway to control surface localization of MHCII, a critical element in DC-dependent immune responses PMID: 18802007
    23. SWAP-70 deficient mice exhibit B cell anomalies including increased autoantibody production and impaired isotype switching. PMID: 11500831

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Cytoplasm, cytoskeleton.
  • 组织特异性：
    Spleen. Expressed only in B-cells that have been induced to switch to various Ig isotypes.
  • 数据库链接：

    KEGG: mmu:20947

    STRING: 10090.ENSMUSP00000033325

    UniGene: Mm.334144