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  4. Recombinant Mouse Suppressor of cytokine signaling 6 (Socs6)

Recombinant Mouse Suppressor of cytokine signaling 6 (Socs6)

  • 货号：
    CSB-YP022395MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022395MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022395MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022395MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022395MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Socs6; Cis4; Cish4; Socs4Suppressor of cytokine signaling 6; SOCS-6; Cytokine-inducible SH2 protein 4; CIS-4; Suppressor of cytokine signaling 4; SOCS-4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-533
  • 氨基酸序列
    MKKISLKTFR KSFNLSKSKD ETEFMVVQPQ SLAGDFVKDD SLFGSCYGKD MASCDIGSED EKGKNRSKSE SLMGTLKRRL SAKQKTKGKG GTASTDEDTF SSASAPGGLK DVRAPRPIRS TSLRSHHYSP TPWPLRPTSS EETCIKMEMR VKALVHAASP GPVNGVRKDL RELQPRELRD LQPEPRPESR CSPSSPGDLS LHLEEHVPVV IGLMSQDYLQ YTVPLDDGMC PLEGPRSCCL DTSSPMEVSA VPLPGASGAF SEDDSHVDQD LVVGPEILVD SSVNNLLIGT TGVMLQSPRG GHDDAPPLSP LLPPMQNNPI QRNFSGLSGP DLHMAESVRC HLNFDPNSAP GVARVYDSVQ SSGPMVVTSL TEELKKLAKQ GWYWGPITRW EAEGKLANVP DGSFLVRDSS DDRYLLSLSF RSHGKTLHTR IEHSNGRFSF YEQPDVEGHT SIVDLIEHSI RDSENGAFCY SRSRLPGSAT YPVRLTNPVS RFMQVRSLQY LCRFVIRQYT RIDLIQKLPL PNKMKDYLQE KHY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
  • 基因功能参考文献：
    1. Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex. PMID: 26503265
    2. Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6 PMID: 24284072
    3. SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6) PMID: 12052866
    4. SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events. PMID: 12396724
    5. SOCS6 has a role as a negative regulator of receptor tyrosine kinases PMID: 14707129
    6. SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase PMID: 15123678
    7. TH1-specific chromatin structure is created by early recruitment of Swi-SNF complexes and nucleosome remodeling dependent on Stat4. PMID: 16717115

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  • 数据库链接：

    KEGG: mmu:54607

    STRING: 10090.ENSMUSP00000064929

    UniGene: Mm.476577