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  4. Recombinant Mouse Solute carrier family 40 member 1 (Slc40a1), partial

Recombinant Mouse Solute carrier family 40 member 1 (Slc40a1), partial

  • 中文名称：
    小鼠Slc40a1重组蛋白
  • 货号：
    CSB-YP864311MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc40a1重组蛋白
  • 货号：
    CSB-EP864311MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc40a1重组蛋白
  • 货号：
    CSB-EP864311MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc40a1重组蛋白
  • 货号：
    CSB-BP864311MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc40a1重组蛋白
  • 货号：
    CSB-MP864311MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc40a1
  • Uniprot No.：
  • 别名：
    Slc40a1; Fpn1; Ireg1; Slc11a3; Slc39a1; Solute carrier family 40 member 1; Ferroportin-1; Iron-regulated transporter 1; Metal transporter protein 1; MTP1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major iron transporter that plays a key role in balancing cellular and systemic iron levels. Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes. When iron is in excess hepcidin/HAMP levels increase, resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma.
  • 基因功能参考文献：
    1. study indicates that copper is an important player in the regulation of the Slc40a1 gene expression. PMID: 28219768
    2. Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1(C326S/C326S) mice compared to wild-type controls. PMID: 28499927
    3. ferroportin mRNA downregulation depends on M2 subtype polarization of macrophage PMID: 27667162
    4. Fasting upregulates Fpn1 expression in spleen and peritoneal macrophages, probably via a ghrelin/GHSR1a/MAPK signaling pathway. PMID: 28338217
    5. Expression of Hepcidin and Ferroportin in the Placenta, and Ferritin and Transferrin Receptor 1 Levels in Maternal and Umbilical Cord Blood in Pregnant Women with and without Gestational Diabetes PMID: 27483296
    6. findings show that ferroportin expression by macrophages at the site of injury represents a requirement for appropriate activation of myogenic precursors and eventual healing of injured skeletal muscle PMID: 27465531
    7. these results indicate that Fpn deficiency decreases Mn trafficking out of the brain, alters body Fe, Mn, Zn and Cu levels, and promotes metal accumulation in olfactory bulbs. PMID: 26693922
    8. The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells. PMID: 26506980
    9. In Angiotensin II treated mice, duodenal divalent metal transporter-1 and ferroportin expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced. PMID: 25096756
    10. Fpn plays a central role in Mn transport and flatiron (ffe/+) mice provide an excellent genetic model to explore the role of this exporter in Mn homeostasis. PMID: 25782988
    11. Mice infected with Salmonella typhimurium have increased duodenal expression of the iron exporter ferroportin-1, consistent with increased uptake of dietary iron. PMID: 25824831
    12. Results suggest that reduction in ferroportin levels in Alzheimer's disease brains are likely associated with cerebral ischaemia, inflammation, loss of neurons due to protein misfolding, senile plaque formation and possibly ageing process itself PMID: 24252754
    13. Oral iron failed to be utilized by Fpn-KO mice and was retained in enterocytes, irrespective of the iron source. Ferroportin-dependent efflux from enterocytes controls duodenal iron absorption. PMID: 24776745
    14. Genetic interactions between Cp, Mon1a, and the Slc40a1 locus are involved in iron metabolism. PMID: 24121729
    15. Hypoxia signal, stimulated erythropoietin, which affected iron absorption by stabilizing duodenal ferroportin. PMID: 23656253
    16. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. PMID: 23846698
    17. The infection of M.tuberculosis can lead to increased Fn expression and decreased FPN expression in macrophages, and the levels of Fn and FPN in the infected macrophages are both related to the strength of the virulence of M.tuberculosis. PMID: 23837981
    18. Nitric oxide up-regulated the expression of ferroportin-1 (Fpn1), the major cellular iron exporter, in mouse and human cells. PMID: 23630227
    19. Ferroportin transcription following experimentally-induced acute anemia in mice is tissue-specific. PMID: 22921471
    20. Ferroportin expression is detected in Kupffer cells and is markedly enhanced at the basolateral membrane of the renal tubules of Hmox1-deficient mice. PMID: 22992020
    21. CD61 regulates the expression of Slc40a1, which is involved in iron transportation in epithelial tissues. PMID: 23064962
    22. in kidney proximal tubules FPN1 is expressed on the basolateral membrane of S1, S2 and S3 segments; under conditions of increased cellular iron, intracellularly expressed FPN1 traffics to the plasma membrane PMID: 20015204
    23. Expression levels of TNF-alpha and IL-6 were significantly enhanced in Fpn1(LysM/LysM) macrophages lacking Fpn1. PMID: 21705499
    24. HIF-2alpha directly binds to the Fpn promoter and induces its expression, indicating a mechanism of transcriptional regulation of Fpn following changes in systemic levels of iron. PMID: 21419768
    25. Nrf2 regulates iron efflux from macrophages through Fpn1 gene transcription PMID: 21303654
    26. Zinc and cadmium can activate Fpn1 transcription through the Metal Transcription Factor-1. PMID: 20688958
    27. show that Fpn1 is not required in the embryo proper but rather in the extra-embryonic visceral endoderm. PMID: 20702562
    28. MTP1 is downregulated in the reticuloendothelial system during inflammation PMID: 12161425
    29. Hephaestin and Ireg1 expression respond to systemic rather than local signals of iron status. PMID: 12730111
    30. GPI-ceruloplasmin colocalizes on the astrocyte cell surface with the divalent metal transporter IREG1 and is physically associated with IREG1. PMID: 12743117
    31. The rapid and strong induction of FPN1 expression after erythrophagocytosis suggests that FPN1 plays a role in iron recycling PMID: 12907459
    32. The iron responsive element in the SLC40A1 gene is functional and that it controls gene expression through the cytoplasmic iron regulatory protein system. PMID: 14568251
    33. Results show no correlation between the expression levels of the duodenal iron transporters DMT1 and IREG1 and the liver iron content in Hfe (hemochromatosis) knockout mice. PMID: 14618243
    34. Copper regulates macrophage iron recycling and induces Fpn1 expression. PMID: 14973193
    35. Despite changes in copper and iron status, FPN1 mRNA levels are not altered in duodenum, liver, kidney, and spleen. PMID: 14988440
    36. identified decreased Fpn1 expression in placental syncytiotrophoblast cells at late gestation as the mechanism of neonatal iron deficiency in Pcm mutants PMID: 15342464
    37. hepcidin bound to ferroportin in tissue culture cells; after binding, ferroportin was internalized and degraded, leading to decreased export of cellular iron PMID: 15514116
    38. FPN1 is directly involved in the export of iron during erythrocyte-iron recycling by macrophages. PMID: 15665091
    39. Neuronal survival of iron accumulation associates with increased expression of the efflux transporter IREG1. PMID: 15667655
    40. Iron absorption genes(Dcytb,IREG1,DMT1)were expressed at lower levels in mouse caecum and colon than in the duodenum. They are regulated by body iron requirements. PMID: 15764147
    41. There appear to be both probable transcriptional and post-transcriptional control of FPN1 expression by LPS-induced inflammation. The former effect is on mRNA expression and is independent of hepcidin, whereas the latter is IL-6- and hepcidin-dependent PMID: 15932798
    42. hepcidin accumulated in the ferroportin-rich organs, liver, spleen, and proximal duodenum, highlighting the central role of the hepcidin-ferroportin interaction in iron homeostasis PMID: 15933050
    43. define the major sites of ferroportin activity PMID: 16054062
    44. localization, expression, and regulation of ferroportin in both duodenal and macrophage cells PMID: 16081760
    45. dominant inheritance of Fpn-iron overload disease is due to the dominant-negative effects of mutant Fpn proteins PMID: 17077321
    46. Mutations in Fpn resulting in protein mislocalization act in a dominant-negative fashion to cause disease, and the Fpn(ffe) mouse represents the first mouse model of ferroportin disease. PMID: 17289807
    47. the degree of ineffective erythropoiesis (IE) dictates tissue iron distribution and that IE and iron content regulate hepcidin (Hamp1) and other iron-regulatory genes such as Hfe and Cebpa PMID: 17299088
    48. After binding of hepcidin, Fpn is tyrosine phosphorylated at the plasma membrane. PMID: 17475779
    49. Suggest that haptoglobin, by controlling plasma levels of hemoglobin, participates in the regulation of ferroportin expression, thus contributing to the regulation of iron transfer from duodenal mucosa to plasma. PMID: 17919498
    50. dual mechanism of Fpn regulation in bone-marrow-derived macrophages, characterized by early induction of the gene transcription predominantly mediated by haem, followed by iron-mediated post-transcriptional regulation of the exporter. PMID: 18072938

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ferroportin (FP) (TC 2.A.100) family, SLC40A subfamily
  • 组织特异性：
    High expression in spleen, liver, kidney, heart and duodenum.
  • 数据库链接：

    KEGG: mmu:53945

    STRING: 10090.ENSMUSP00000027137

    UniGene: Mm.28756