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  4. Recombinant Mouse Solute carrier family 22 member 8 (Slc22a8), partial

Recombinant Mouse Solute carrier family 22 member 8 (Slc22a8), partial

  • 中文名称：
    小鼠Slc22a8重组蛋白
  • 货号：
    CSB-YP021463MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc22a8重组蛋白
  • 货号：
    CSB-EP021463MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc22a8重组蛋白
  • 货号：
    CSB-EP021463MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc22a8重组蛋白
  • 货号：
    CSB-BP021463MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc22a8重组蛋白
  • 货号：
    CSB-MP021463MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc22a8
  • Uniprot No.：
  • 别名：
    Slc22a8; Oat3; RoctSolute carrier family 22 member 8; Organic anion transporter 3; mOat3; Reduced in osteosclerosis transporter
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Mediates the uptake of p-amino-hippurate (PAH) and estron sulfate (ES). Also mediates uptake of several organic compounds such as prostaglandin E(2), prostaglandin F(2-alpha), allopurinol, 6-mercaptopurine (6-MP), 5-fluorouracil (5-FU), and L-carnitine.
  • 基因功能参考文献：
    1. vitamin D-deficiency resulted in down-regulation of liver Cyp7a1 and renal Oat3, conditions that are alleviated upon replenishment of cholecalciferol. PMID: 29243851
    2. OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney PMID: 28765282
    3. Specifically blocking its transport through OAT3 or antioxidant treatment could prevent CMPF-induced beta cell dysfunction. PMID: 24703697
    4. Oat3 also plays a role in bioenergetic pathways. PMID: 23920220
    5. The results are consistent with a contribution of OAT3 and possibly OAT1 to renal creatinine secretion in mice. PMID: 22338083
    6. DAT and Oct3 modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling PMID: 22143804
    7. Oat3 plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 = SLC22A8 transporter) PMID: 12011098
    8. For PAH, FL, and estrone sulfate, all Oat3-mediated transport was Na dependent in choroid plexus PMID: 15075193
    9. Results indicate that mOAT3 plays a role for the transport of bumetanide on the luminal membranes of kidney proximal tubules. PMID: 16256982
    10. These results indicate that the tissue-specific expression of hOAT3 might be regulated by the concerted effect of genetic (HNF1alpha and HNF1beta) and epigenetic (DNA methylation) factors. PMID: 16793932
    11. mOat3 plays an important role as a basolateral transport pathway of PGE(2) in the distal nephron. PMID: 17220594
    12. urinary excretion of topotecan hydroxyl acid is accounted for by transport via OAT3, as well as glomerular filtration, in both rats and humans PMID: 17556638
    13. Functional Oat3 is necessary for proper elimination of xenobiotic and endogenous compounds in vivo. PMID: 17686950
    14. Oat3 interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. PMID: 18381565
    15. One of its substrates, thymidine, as well as two of the most potent inhibitors that were characterized, reduced blood pressure by 10 to 15%. PMID: 18508962

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Highly expressed in kidney. Expressed in developing bone. Weakly expressed in brain and eye.
  • 数据库链接：

    KEGG: mmu:19879

    STRING: 10090.ENSMUSP00000010251

    UniGene: Mm.285294