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  4. Recombinant Mouse Sodium/myo-inositol cotransporter (Slc5a3), partial

Recombinant Mouse Sodium/myo-inositol cotransporter (Slc5a3), partial

  • 中文名称：
    小鼠Slc5a3重组蛋白
  • 货号：
    CSB-YP878097MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc5a3重组蛋白
  • 货号：
    CSB-EP878097MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc5a3重组蛋白
  • 货号：
    CSB-EP878097MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc5a3重组蛋白
  • 货号：
    CSB-BP878097MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc5a3重组蛋白
  • 货号：
    CSB-MP878097MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc5a3
  • Uniprot No.：
  • 别名：
    Slc5a3Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; Sodium/myo-inositol transporter 1; SMIT1; Solute carrier family 5 member 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function.; Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.
  • 基因功能参考文献：
    1. SMIT1 overexpression contributes to abnormal cholinergic and glutamatergic Ca(2+) signals in the trisomic condition PMID: 28695546
    2. Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior PMID: 27922641
    3. KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability. PMID: 24595108
    4. activation of NFAT5 and its downstream SMIT induction is important in protecting neurons from ischemia-induced oxidative stress PMID: 23172129
    5. At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification PMID: 22564531
    6. These findings add Mus spicilegus endogenous retrovirus HEMV as a second member to the murine leukemia virus subgroup that uses mSMIT1 to gain entry into cells. PMID: 22457525
    7. brain SMIT1 levels were higher than SMIT2, however, regional differences were observed PMID: 21887366
    8. Sodium/MI cotransporter 1 (SMIT1, the major cotransporter of MI) knockout (SMIT1(-/-)) mice with markedly reduced tissue myoinositol (MI) levels were used to characterize the essential roles of MI and SMIT1 in osteogenesis. PMID: 20818642
    9. SLC5a3 is responsible for the Ins concentration gradient in the murine fetal-placental unit PMID: 12582158
    10. used by Mus cervicolor Murine Leukemia Virus for cell entry PMID: 12719585
    11. When Sertoli cells were cultured in a hypertonic medium, there was an increase in the expression of Isyna1 and Slc5a3 PMID: 14613899
    12. SMIT-1 has a role in the development and function of the peripheral nerves PMID: 16174787
    13. Mrps6 gene expression may not be contingent on function of Slc5a3 gene, while inositide deficiency may not be the cause of lethal apnea in null Slc5a3 mice. PMID: 18675571

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:solute symporter (SSF) (TC 2.A.21) family
  • 数据库链接：

    KEGG: mmu:53881

    STRING: 10090.ENSMUSP00000109608

    UniGene: Mm.217354