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  4. Recombinant Mouse Sodium/glucose cotransporter 1 (Slc5a1), partial

Recombinant Mouse Sodium/glucose cotransporter 1 (Slc5a1), partial

  • 货号：
    CSB-YP806016MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806016MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806016MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806016MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806016MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Slc5a1; Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
  • 基因功能参考文献：
    1. results suggest that rhythmic expression of Sglt1 is regulated at the mRNA transcriptional elongation level by enhancing the binding of the BRD4-P-TEFb complex to acetylated histones at the gene upon BMAL1-CLOCK binding to Sglt1 PMID: 29557282
    2. SGLT1 deficiency turns Listeria infection into a lethal disease in mice. PMID: 28704812
    3. sodium influx through cerebral SGLT-1 may exacerbate cerebral ischemia-induced neuronal damage PMID: 28174043
    4. JAK3 up-regulates SGLT1 activity by increasing the carrier protein abundance in the cell membrane, an effect enforcing cellular glucose uptake into activated lymphocytes and thus contributing to the immune response. PMID: 27595398
    5. Enhanced cerebral sodium-glucose transporter function mediated by post-ischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage. PMID: 26454021
    6. These findings support the involvement of SGLT1 in post-oral glucose and MDG conditioning. PMID: 26791832
    7. Compound K upregulates SGLT1 expression in vivo in mice. PMID: 25600494
    8. Studied leptin and CST modulation of SGLT1 expression in hyperleptinemic type 2 diabetic mice. PMID: 26552046
    9. Cardiac knockdown of SGLT1 in a murine model of PRKAG2 cardiomyopathy attenuates the disease phenotype, implicating SGLT1 in the pathogenesis. Overexpression of SGLT1 causes pathologic cardiac hypertrophy and left ventricular failure that is reversible. PMID: 25092788
    10. In conclusion, SPAK is a powerful negative regulator of SGLT1 protein abundance in the cell membrane and thus of electrogenic glucose transport. PMID: 25161031
    11. These results suggest that cerebral SGLT is activated by post-ischemic hyperglycemia and may be involved in the exacerbation of ischemic neuronal damage. PMID: 23078759
    12. Improved glycemic control in mice lacking Sglt1 and Sglt2. PMID: 23149623
    13. Data suggest that the absence of intestinal microbiota alters expression of (i.e., up-regulates) Sglt1 and Tas1r3 in proximal small intestine, factors associated with increased consumption of nutritive sweet solutions. PMID: 21781379
    14. SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. PMID: 22124465
    15. Effect of cadmium on SGLT1 mRNA levels and alpha-methyl D-glucopyranoside uptake studied in mouse kidney cortical cells PMID: 11749115
    16. loads, capacities and safety factors in mouse intestinal brush border PMID: 12122147
    17. SGLT1 cotransport of Na+-D-glucose in the small intestine is regulated by Rsc1A1 PMID: 15601832
    18. Dietary sugar and artificial sweeteners increased SGLT1 mRNA and protein expression, and glucose absorptive capacity in wild-type mice, but not in knockout mice lacking T1R3 or alpha-gustducin. PMID: 17724332
    19. Homozygote knockout mice of slc5a1, free inositol levels were reduced by 55% in the frontal cortex and by 60% in the hippocampus. PMID: 18452441
    20. activation of SGLT-1 by glucose protects from damages induced by TLR ligands, in human intestinal epithelial cells and in a murine model of septic shock. PMID: 18713983
    21. The GIP-induced increase in glucose transport appears to be mediated, at least in part, by SGLT-1. PMID: 18719661
    22. Induction of SGLT1 gene expression by feeding a high carbohydrate/fat ratio diet is associated with acetylation of histone H3 at lysine 9 on the SGLT1 gene. PMID: 18952408
    23. dmRNA expression of SGLT1 varied diurnally in the duodenum, jejunum, and ileum mucosa. SGLT1 protein level varied diurnally in duodenum and jejunum, but not in the ileum PMID: 19082670
    24. Amino acids in TM1, which are not involved in ligand binding and translocation pathways, significantly influence the functional properties of sodium-glucose carrier proteins. PMID: 19122974
    25. cardiac SGLT1 expression and/or function are regulated by insulin and leptin, and are perturbed in disease. PMID: 19509029
    26. SGLT1 triggers incretin secretion without the need for subsequent glucose metabolism. PMID: 19808907

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:solute symporter (SSF) (TC 2.A.21) family
  • 数据库链接：

    KEGG: mmu:20537

    STRING: 10090.ENSMUSP00000011178

    UniGene: Mm.25237