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  4. Recombinant Mouse Signal transducer and activator of transcription 5B (Stat5b)

Recombinant Mouse Signal transducer and activator of transcription 5B (Stat5b)

  • 货号：
    CSB-YP022815MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022815MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022815MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022815MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022815MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stat5b; Signal transducer and activator of transcription 5B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-786
  • 氨基酸序列
    MAMWIQAQQL QGDALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSIDLDN PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQSTYDR CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE LRLITQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFAQLG QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFDSQFSV GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNI SSNHLEDYNS MSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCEP ATAKAADGYV KPQIKQVVPE FANASTDAGS GATYMDQAPS PVVCPQAHYN MYPPNPDSVL DTDGDFDLED TMDVARRVEE LLGRPMDSQW IPHAQS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
  • 基因功能参考文献：
    1. NK cell numbers are decreased in Stat5a-Stat5b tetramer-deficient double knockin mice, but the mechanism was not investigated. Here we show that STAT5 dimers are sufficient for NK cell development, whereas STAT5 tetramers mediate NK cell maturation and the expression of maturation-associated genes PMID: 29105654
    2. Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B-directed responses. PMID: 28219718
    3. STAT5B is a crucial regulator of RICD in memory T cells in mice PMID: 29187589
    4. Our work is the first to report that an active form of Stat5b restored DCs tolerogenic functions that re-educated Tregs to re-establish and to sustain long-term protective immune response against diabetes in NOD mice. PMID: 27634616
    5. Data indicate that 89% of signal transducer and activator of transcription 5 (Stat5b)-CA mice in which the T2/Onc transposon had been mobilized died of progenitor B-cell acute lymphoblastic leukemia (B-ALL) by 3 months of age. PMID: 26500062
    6. STAT5B and MOF work as negative regulators in adipogenesis. PMID: 26388045
    7. liver STAT5b activation/masculinization occurred at puberty and suppression/feminization occurred during aging and in mutant mice with defects in growth hormone signaling. PMID: 26959975
    8. Loss of STAT5b had no effect on either sex. PMID: 24838184
    9. Increased expression of STAT5b + PDGFB led to increased expression of downstream STAT5b targets. PMID: 25302990
    10. non-obese-diabetic genetic background is critical to the Stat5b-mediated lymphomagenesis through regulation of Stat5 hyperactivation PMID: 23457589
    11. Stat5b confers protection against diabetes in the NOD mice by regulating the numbers and function of multiple immune cell types, especially by up-regulating CD4(+)CD25(+) regulatory T cells. PMID: 22789848
    12. STAT5 is a negative regulator of Follicular Helper (TFH) CD4+ T cell differentiation, primarily through regulation of the transcription factor Blimp-1. PMID: 22271576
    13. CPEB3 has a novel function in the nucleus as to suppress Stat5b-dependent EGFR gene transcription PMID: 20639532
    14. rigorously Treg-depleted Stat5b-CA TG versus WT CD4(+)CD25(-) Teffs caused less GVHD lethality associated with diminished Teff proinflammatory and increased Th2 anti-inflammatory cytokine responses PMID: 20442366
    15. Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). PMID: 12040024
    16. Stat5 regulated expression of peroxisome proliferator-activated receptor-gamma.These results highlight a novel role of Stat5 in adipocyte differentiation. PMID: 12089351
    17. Whereas Stat5b-/- knockout mice have decreased numbers of CD8+ memory cells, transgenic Stat5b expression markedly increases CD8+ memory T cell numbers, indicating its critical role in regulating homeostasis of this cell population. PMID: 12496402
    18. STAT 5 proteins are not activated by physiological levels of insulin in adipose tissue. PMID: 12604355
    19. A subset of STAT5B-deficient mice exhibit autoimmune pathology very similar to mice lacking IL-2 or its receptor components, characterized by lymphocytic infiltration of multiple organs, including the bone marrow. PMID: 14607901
    20. Stat5b pathway is a key molecular defect in NOD mice PMID: 14701862
    21. prolactin activation of Stat5b is important in suppressing 20alpha-HSD gene expression and thereby allowing the maintenance of progesterone levels that are required to sustain pregnancy PMID: 15471942
    22. STAT5b plays a critical role during steady-state hematopoietic stem cell engraftment and a chromosome 7 modifier locus regulates this activity. PMID: 15498858
    23. Results are consistent with the hypothesis that STAT5 proteins are involved in the feedback regulation of somatostatin neurones by GH, and that these neurones may respond to patterned GH secretion to reinforce sexual dimorphism in the GH axis. PMID: 15796771
    24. Our results suggest the potential involvement of STAT5b in Lck-mediated cellular transformation. PMID: 16446405
    25. Several female-predominant repressors are elevated in STAT5b-deficient males; these may contribute to the major loss of male gene expression seen in the absence of STAT5b. PMID: 16469768
    26. The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 and preventing its dephosphorylation. PMID: 16622421
    27. STAT5B protein function in preimplantation development by mediating the signals from cytokines PMID: 16775227
    28. we generated transgenic mice that expressed a constitutive active mutant of STAT5b (CASTAT5) under control of rat insulin 1 promoter. When subjected to high-fat diet, RIP-CASTAT5 mice were more glucose tolerant & less hyperleptinemic than wild-type mice. PMID: 17003334
    29. Therapeutic activation of the GH:STAT5b axis therefore represents a novel target for restoring both normal anabolic metabolism and mucosal tolerance in CD. PMID: 17148664
    30. the major loss of liver sexual dimorphism in hepatocyte STAT5ab-deficient mice can primarily be attributed to the loss of STAT5b PMID: 17317776
    31. JAK-Stat5B defective pathway in NOD mice along with other defective factors is associated with the pathogenesis of autoimmune type 1 diabetes in NOD mice. PMID: 17382905
    32. The transcription factor Stat5b is not required for islet development but modulates beta-cell physiology upon aging. PMID: 17599554
    33. Stat5b directly control IL-7-mediated early B cell development but are not required for B cell maturation and Ig production PMID: 17617599
    34. alterations in T-cell development at the double-negative/double-positive (DN/DP) stages cooperate with cytokine-mediated pathways in immature thymocytes to give rise to lymphoblastic T-cell lymphomas in Stat5b TG mice PMID: 17890450
    35. murine OSMR initiates STAT5 activation directly via the receptor bound Janus kinases. Intriguingly, the murine receptor preferentially recruits JAK2, whereas the human receptor seems to have a higher affinity for JAK1. PMID: 18430728
    36. The enhanced SULT1E1 activity may have a role in inhibiting GH-stimulated STAT5b phosphorylation and IGF-1 synthesis via the sulfation and inactivation of E2. PMID: 18831980
    37. STAT5b signaling is critical for leukemia stem cell self-renewal in MN1- and HOXA9-expressing leukemias. PMID: 19667399

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
  • 蛋白家族：
    Transcription factor STAT family
  • 组织特异性：
    In the virgin, found in most tissues. Particularly abundant in muscle tissue of virgin and lactating females, and of males.
  • 数据库链接：

    KEGG: mmu:20851

    STRING: 10090.ENSMUSP00000004143

    UniGene: Mm.34064