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  4. Recombinant Mouse Serpin B5 (Serpinb5)

Recombinant Mouse Serpin B5 (Serpinb5)

  • 货号：
    CSB-YP021073MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021073MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021073MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021073MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021073MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Serpinb5; Pi5; Spi5; Spi7; Serpin B5; Maspin; Peptidase inhibitor 5; PI-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-375
  • 氨基酸序列
    MDALRLANSAFAVDLFKQLCERDPAGNILFSPICLSTSLSLAQVGTKGDTANEIGQVLHF ENVKDVPFGFQTVTSDVNKLSSFYSLKLVKRLYIDKSLNPSTEFISSTKRPYAKELETVD FKDKLEETKGQINSSIKELTDGHFEDILSENSISDQTKILVVNAAYFVGKWMKKFPESET KECPFRISKTDTKPVQMMNLEATFCLGNIDDISCKIIELPFQNKHLSMLIVLPKDVEDES TGLEKIEQQLNPETLLQWTNPSTMANAKVKLSLPKFKVEKMIDPKASLESLGLKSLFNES TSDFSGMSETKGVSLSNVIHRVCLEITEDGGESIEVPGSRILQHKDEFNADHPFIYIIRH NKTRNIIFFGKFCSP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
  • 基因功能参考文献：
    1. maspin is a powerful context-dependent tumor suppressor. PMID: 27923833
    2. these data indicate that SerpinB5 expression and phosphorylation are developmentally regulated. In vitro analyses indicate that SerpinB5 phosphorylation is regulated by EGFR ligands, but EGF appears to be the only able to induce SerpinB5 nuclear localization. PMID: 27447178
    3. perturbation of genes near maspin may in fact explain poor survival in certain patient cohorts with low maspin expression PMID: 24445777
    4. evidence demonstrates that D(346) is a critical cis-element in maspin sequence that determines the molecular context and subcellular localization of maspin. PMID: 24278104
    5. a novel mechanism by which maspin utilizes its cysteine thiols to inhibit oxidative stress and cell growth. PMID: 23471964
    6. results suggest that maspin, a tumor suppressor, may play an important role in embryo implantation PMID: 22776050
    7. The nuclear localization of maspin is required for its tumor and metastasis suppressor functions in vivo. PMID: 21502940
    8. SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma PMID: 20939879
    9. PAR-1 negatively regulates the expression of the Maspin tumor-suppressor gene in the acquisition of the metastatic melanoma phenotype PMID: 21187389
    10. Results describe a mechanism by which maspin exerts its effect on endothelial cell adhesion and migration through an integrin signal transduction pathway. PMID: 20713357
    11. maspin exerts its tumor suppressive role, at least in part, by blocking the pericellular uPA system PMID: 12788977
    12. Results show that deletion of maspin affects visceral endoderm function by reducing cell proliferation and adhesion, thereby controlling early embryonic development. PMID: 14985257
    13. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl2 family proteins PMID: 15907209
    14. we believe that maspin is a tumour suppressor in malignant melanoma. PMID: 17371437
    15. We propose that tumour-infiltrating RANKL-expressing cells lead to nuclear IKKalpha activation and inhibition of Maspin transcription, thereby promoting the metastatic phenotype PMID: 17377533
    16. A partial loss of maspin caused an early developmental defect of the prostate and prostate hyperplastic lesions in mouse. PMID: 18593913

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  • 亚细胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 数据库链接：

    KEGG: mmu:20724

    STRING: 10090.ENSMUSP00000083908

    UniGene: Mm.268618