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  4. Recombinant Mouse Serine/threonine-protein kinase 40 (Stk40)

Recombinant Mouse Serine/threonine-protein kinase 40 (Stk40)

  • 中文名称：
    小鼠Stk40重组蛋白
  • 货号：
    CSB-YP763168MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stk40重组蛋白
  • 货号：
    CSB-EP763168MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stk40重组蛋白
  • 货号：
    CSB-EP763168MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stk40重组蛋白
  • 货号：
    CSB-BP763168MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stk40重组蛋白
  • 货号：
    CSB-MP763168MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stk40
  • Uniprot No.：
  • 别名：
    Stk40; Lyk4; Serine/threonine-protein kinase 40; EC 2.7.11.1; Serine/threonine-protein kinase lyk4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-435
  • 氨基酸序列
    MKRRASDRGA GETSANAKAL GTGIAGNNAK RAGPFVLGPR LGNSPVPSIV QCLARKDGTD DFYQLKILTL EERGEQGIES QEERQGKMLL HTEYSLLSLL HTQDGVVHHH GLFQDRTCEA VEDTESGRMV KKMKKRICLV LDCLCAHDFS DKTADLINLQ HYVIKEKRLS ERETVVIFYD VVRVVEALHQ KNIVHRDLKL GNMVLNKRTH RITITNFCLG KHLVSEGDLL KDQRGSPAYI SPDVLSGRPY RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS ENTVCLIRKL LVLDPQQRLA AADVLEALSA IIASWQSLSS LSGPLQVVPD IDDQMSSSDS SQEAKVTEEC SQYEFENYMR QQLLLAEEKS SIHEARAWVP KRQFGSMPPV RRLGHDAQPM TSLDTAILAQ RYLRK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
  • 基因功能参考文献：
    1. comparison of microarray data between wild type and Stk40(-/-) E14.5 fetal liver cells reveals a potential role of aberrantly activated TNF-alpha signaling in Stk40 depletion induced dyserythropoiesis with a concomitant increase in cleaved caspase-3 and decrease in Gata1 proteins. PMID: 28358362
    2. Loss of Stk40 is associated with impaired fetal skeletal muscle formation. PMID: 27899448
    3. CCAAT/enhancer-binding protein (C/EBP) beta and C/EBPdelta, two crucial pro-adipogenic transcription factors, are controlled at a translational level by serine/threonine kinase 40 (Stk40). PMID: 26065429
    4. the results suggested that Stk40 may be critical in the development of preimplantation embryos. PMID: 24276375
    5. Deletion of STK40 protein in mice causes respiratory failure and death at birth PMID: 23293024
    6. report identification of a target gene of Oct4, serine/threonine kinase 40 (Stk40), which is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse embryonic stem cells. PMID: 20080709

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 数据库链接：

    KEGG: mmu:74178

    STRING: 10090.ENSMUSP00000111990

    UniGene: Mm.440269