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  4. Recombinant Mouse Serine racemase (Srr)

Recombinant Mouse Serine racemase (Srr)

  • 货号：
    CSB-YP022691MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022691MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022691MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022691MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022691MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Srr
  • Uniprot No.：
  • 别名：
    Srr; Serine racemase; EC 5.1.1.18; D-serine ammonia-lyase; D-serine dehydratase; EC 4.3.1.18; L-serine ammonia-lyase; L-serine dehydratase; EC 4.3.1.17
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-339
  • 氨基酸序列
    MCAQYCISFA DVEKAHINIQ DSIHLTPVLT SSILNQIAGR NLFFKCELFQ KTGSFKIRGA LNAIRGLIPD TPEEKPKAVV THSSGNHGQA LTYAAKLEGI PAYIVVPQTA PNCKKLAIQA YGASIVYCDP SDESREKVTQ RIMQETEGIL VHPNQEPAVI AGQGTIALEV LNQVPLVDAL VVPVGGGGMV AGIAITIKAL KPSVKVYAAE PSNADDCYQS KLKGELTPNL HPPETIADGV KSSIGLNTWP IIRDLVDDVF TVTEDEIKYA TQLVWGRMKL LIEPTAGVAL AAVLSQHFQT VSPEVKNVCI VLSGGNVDLT SLNWVGQAER PAPYQTVSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
  • 基因功能参考文献：
    1. Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow. PMID: 27693471
    2. These findings reveal the NMDAR-independent roles of SR in metabolism and cell survival. PMID: 27585868
    3. These data reveal the first evidence that Srr may regulate glucose homeostasis in peripheral tissues and provide circumstantial evidence that D-serine may be an endogenous islet NMDAR co-agonist in beta-cells. PMID: 27880078
    4. This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF, and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis. PMID: 28892569
    5. results indicate that SRR indeed acts as a d-Asp biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp synthesis in mammals. PMID: 27387750
    6. data show neuronal serine racemase could regulate the extracellular D-serine signaling responsible for N-methyl-D-aspartate type glutamate receptor activation in the hippocampus PMID: 25782690
    7. The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in Serine racemase. PMID: 25083578
    8. In the neocortex and hippocampus only 24-40% of interneurons expressed serine racemase. PMID: 24436034
    9. SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-95) and stargazin, forming a ternary complex. PMID: 25164819
    10. The findings of this study suggest that D-serine-dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation. PMID: 24269270
    11. serine racemase in the skin epidermis is involved in the differentiation of epidermal keratinocytes and the formation of the skin barrier PMID: 24441099
    12. Disruption of D-serine synthesis, by blocking SRR, during developmental stages leads to behavioral abnormalities relevant to prodromal symptoms and schizophrenia. PMID: 23630632
    13. SRR and/or d-serine may be involved in the production of d-aspartic acid in mouse forebrains PMID: 23439386
    14. The serine racemase-null mutant mouse has less than 10% of normal brain D-serine in a model of schizophrenia PMID: 23729812
    15. The present findings suggest that serine racemase may be a target for the development of new therapeutic strategies for epileptic seizures. PMID: 22742962
    16. Serine racemase is expressed by the main neuronal populations in most brain regions, irrespective of the excitatory or inhibitory nature of the cells. (Review) PMID: 22847782
    17. Serine racemase is the major enzyme responsible for D-serine production in the mouse forebrain. Other pathways of D-serine production may exist in the brain and peripheral organs. PMID: 21906644
    18. In forebrain, serine racemase is predominantly expressed in glutamatergic neurons, and co-release of glutamate and D-serine is required for optimal activation of post-synaptic NMDA receptors. PMID: 22362148
    19. SRR-/- mice exhibited a significantly disrupted representation of the order of events in distinct experiences as showed by object recognition and odor sequence tests PMID: 21029376
    20. Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of serine racemase mutant mice despite evidence of increased NMDA receptor number and sensitivity. PMID: 20107067
    21. Direct calcium binding results in activation in brain PMID: 12021263
    22. Serine racemase is a bifunctional enzyme, producing both d-serine and pyruvate in cultured cells and in vitro PMID: 12393813
    23. in addition to serine racemization, brain serine racemase also catalyzes specific elimination of L-serine to pyruvate; D-serine is eliminated much less efficiently PMID: 12560076
    24. Modulation of serine racemase degradation provides a new mechanism for regulating brain d-serine levels and NMDA receptor activity. PMID: 16714286
    25. These findings support a model whereby postsynaptic stimulation of nitric-oxide (NO) formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors. PMID: 17293453
    26. This is the first report of neuronal expression of D-serine and serine racemase in the veretebrate retina during development. PMID: 17976164
    27. plays a role in biosynthesis of free D-amino acid. PMID: 18516911
    28. REsults suggest that serine racemase is expressed in many types of neurons in the brain and plays a key role in the regulation of brain functions under physiological and pathological conditions via the production of the neuromodulator D-serine. PMID: 18698599
    29. this study show that genetically modified mice lacking the ability to produce D-serine endogenously have profoundly altered glutamatergic neurotransmission, and relatively subtle but significant behavioral abnormalities. PMID: 19065142
    30. Srr mutant mice display behavioral phenotypes relevant to schizophrenia. PMID: 19483194

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  • 蛋白家族：
    Serine/threonine dehydratase family
  • 组织特异性：
    Detected in brain (at protein level). Brain.
  • 数据库链接：

    KEGG: mmu:27364

    STRING: 10090.ENSMUSP00000067552

    UniGene: Mm.131443