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  4. Recombinant Mouse Rho guanine nucleotide exchange factor 6 (Arhgef6)

Recombinant Mouse Rho guanine nucleotide exchange factor 6 (Arhgef6)

  • 货号：
    CSB-YP813003MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP813003MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP813003MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP813003MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP813003MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Arhgef6Rho guanine nucleotide exchange factor 6; Alpha-PIX; Rac/Cdc42 guanine nucleotide exchange factor 6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-771
  • 氨基酸序列
    MNPEERLVTW LISLGVLESP KKTVCDPEEF LKSSLKNGVV LCKLINRLLP GSVEKYCLEP QTEADCIDNI NDFLKGCATL QVEVFEPDDL YSGANFSKVL NTLLAVNKAT EDQLSERPCG RSSSLSAATS SQTNPQVAVP STAPEQHSEE KAEMTENGSH QLIVKARFNF KQTNEDELSV CKGDIIYVTR VEEGGWWEGT LNGRTGWFPS NYVREIKPSE RPLSPKAIKG FDTAPLTKNY YTVVLQNILD TEKEYAKELQ SLLVTYLRPL QSNNNLSTVE FTCLLGNFEE VCTFQQTLCQ ALEECSKFPE NQHKVGGCLL NLMPHFKSMY LAYCANHPSA VNVLTQHSDD LERFMENQGA SSPGILILTT SLSKPFMRLE KYVTLLQELE RHMEDTHPDH QDILKAIIAF KTLMGQCQDL RKRKQLELQI LSEPIQAWEG DDIKTLGNVI FMSQVVMQHG ACEEKEERYF LLFSSVLIML SASPRMSGFM YQGKIPIAGM VVNRLDEIEG SDCMFEITGS TVERIVVHCN NNQDFQEWME QLNRLTKGPT SCGSLSKTSS SSCSTHSSFS STGQPRGPLE PPQIIKPWSL SCLRPAPPLR PSAALGYKER MSYILKESSK SPKTMKKFLH KRKTERKASE EEYVIRKSTA ALEEDAQILK VIEAYCTSAS FQQGTRKDSV PQVLLPEEEK LIIEETRSNG QTIIEEKSLV DTVYALKDEV KELKQENKKM KQCLEEELKS RKDLEKLVRK LLKQTDECIR SESSSKTSIL Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a RAC1 guanine nucleotide exchange factor (GEF).
  • 基因功能参考文献：
    1. this study has identified a new role for Parvin and alphaPix downstream of the integrin-ILK signaling axis for mammary epithelial cell differentiation. PMID: 27019299
    2. Enforced expression of miR-135a in highly tumorigenic cancer stem cells strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6. PMID: 25639612
    3. Results indicate Arhgef6 (alphaPIX) as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection. PMID: 24591366
    4. alphaPIX and GIT2 are required for neuronal differentiation. PMID: 22554054
    5. suggest that imbalance in activity of different Rho GTPases may underlie altered neuronal connectivity and impaired synaptic function and cognition in alphaPix/Arhgef6 knockout mice PMID: 21989057
    6. The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment. PMID: 12063400
    7. ARHGEF6 is localized in dendritic spines where it contributes to regulate dendritic spine morphogenesis. PMID: 17105769
    8. These results reveal specific roles for alphaPIX in the immune system and suggest that redundancy with betaPIX precludes a more severe immune phenotype. PMID: 18378701

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  • 亚细胞定位：
    Cell projection, lamellipodium.
  • 组织特异性：
    Detected in adult heart, spleen, lung, skeletal muscle, kidney and testis. Detected throughout embryogenesis.
  • 数据库链接：

    KEGG: mmu:73341

    STRING: 10090.ENSMUSP00000033468

    UniGene: Mm.261443