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  4. Recombinant Mouse Retinal homeobox protein Rx (Rax)

Recombinant Mouse Retinal homeobox protein Rx (Rax)

  • 中文名称：
    小鼠Rax重组蛋白
  • 货号：
    CSB-YP019384MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rax重组蛋白
  • 货号：
    CSB-EP019384MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rax重组蛋白
  • 货号：
    CSB-EP019384MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rax重组蛋白
  • 货号：
    CSB-BP019384MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rax重组蛋白
  • 货号：
    CSB-MP019384MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rax
  • Uniprot No.：
  • 别名：
    Rax; RxRetinal homeobox protein Rx; Retina and anterior neural fold homeobox protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-342
  • 氨基酸序列
    MHLPGCAPAM ADGSFSLAGH LLRSPGGSTS RLHSIEAILG FTKEDGILDT FPAERSSRSS KERDPRLGAQ PACPKAPAGG SESSPPAAPG FVPEYEATRP CYPKEQGEAR PSPGLSVGPA AGDSKLSEEE PPKKKHRRNR TTFTTYQLHE LERAFEKSHY PDVYSREELA GKVNLPEVRV QVWFQNRRAK WRRQEKLEVS SMKLQDSPLL SFSRSPPSSA LAPLGTGPGS GSGPPGSALP LEPWLGPPLP GGGATALQSL PGFGPPGQGL PASYTPPPPF LNSAPLGPGL QQLGPPPAYP CAPAFGDKFS LEEAYPRNSS IAALRLKAKE HIQAIGKPWQ AL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
  • 基因功能参考文献：
    1. Deletion of Rax in the eye generated loss of central visual pathways and the suprachiasmatic nucleus was absent. PMID: 28675567
    2. the role of Rax in the early stages of hypothalamic development PMID: 27212025
    3. Rax and Crx cooperatively transactivate Rhodopsin and cone opsin promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists. PMID: 25986607
    4. This study provided evidence that Rax is required for the normal differentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cerebrospinal fluid-hypothalamus barrier. PMID: 23939786
    5. our study illustrates that Rax is required in ARC/VMH progenitors to specify neuronal phenotypes within this hypothalamic brain region. PMID: 23283339
    6. This study demonistrated that the RAX homeoprotein interacts with embryonic enhancer locus for photoreceptor Otx2 transcription to transactivate Otx2, mainly in the final cell cycle of retinal progenitors PMID: 22090505
    7. subpopulations of retinal neurons can be generated in retinal explant cultures from grafted mouse ES cells ectopically expressing the transcription factor Rx/rax PMID: 15121868
    8. These findings in mice and Drosophila illustrate the importance of RAX for embryonic development. PMID: 18634873
    9. Development of auxiliary eye structures does not depend on retina-specific gene expression or retinal morphogenesis. Lens formation involves beta-catenin expression in the head surface ectoderm. PMID: 18675797
    10. Rx function is not only required for the morphogenesis of the retina and posterior pituitary, but also prior to morphogenesis, for the sorting out of cells to form distinct fields of retinal/pituitary cells. PMID: 19229337

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family, Bicoid subfamily
  • 组织特异性：
    Expressed in the photoreceptor and inner nuclear layers.
  • 数据库链接：

    KEGG: mmu:19434

    STRING: 10090.ENSMUSP00000025396

    UniGene: Mm.431047