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  4. Recombinant Mouse Regulator of G-protein signaling 2 (Rgs2)

Recombinant Mouse Regulator of G-protein signaling 2 (Rgs2)

  • 中文名称：
    小鼠Rgs2重组蛋白
  • 货号：
    CSB-YP019651MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rgs2重组蛋白
  • 货号：
    CSB-EP019651MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rgs2重组蛋白
  • 货号：
    CSB-EP019651MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rgs2重组蛋白
  • 货号：
    CSB-BP019651MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rgs2重组蛋白
  • 货号：
    CSB-MP019651MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rgs2; Regulator of G-protein signaling 2; RGS2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSAPGKPKT GKKSKQQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKSLIAQ NIQEATSGCF TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
  • 基因功能参考文献：
    1. PKC activation appeared to increase the RGS2 translocation from nucleus to cytosol. PKA- and PKC-mediated RGS2 transcription in a Sp-1-dependent manner and a PKC-mediated RGS2 intracellular translocation were noted in granulosa cells. PMID: 29932914
    2. Results confirmed the regulator of G-Protein signaling 2 (RGS2) as an interaction partner of PKGI-alpha. PMID: 29649180
    3. The present results suggest that expression of the eIF2B-interacting domain of RGS2, RGS2eb, can protect against pathological cardiac hypertrophy and dysfunction in vivo. PMID: 28641980
    4. RGS2 has critical roles in maintaining pancreatic beta-cell mass via modulating beta-cell function and apoptosis. PMID: 28542139
    5. Results show that RGS2 negatively modulates D2R-mediated Galphai/o protein signaling in neuroblastoma N2A cells. Moreover, RGS2 critically regulates agonist-stimulated dopamine D2R internalization. RGS2 knockdown abolished quinpirole-stimulated D2R internalization and impaired beta-arrestin dissociation from the membrane. PMID: 27528587
    6. Upregulated RGS2 contributes significantly to the anti-fibrotic effects of pirfenidone in idiopathic pulmonary fibrosis. PMID: 27549302
    7. Modest anti-inflammatory and anti-remodelling roles for RGS2 are also suggested. If translatable to humans, therapies that maximize RGS2 expression may prove advantageous PMID: 28107494
    8. RGS2 might play a critical role in mouse oocyte meiotic maturation by affecting beta-tubulin polymerization and chromosome segregation. PMID: 27463806
    9. Knockdown of endogenous Rgs2 expression led to abnormal embryonic development in vitro, with a considerable number of early embryos arrested at the 2- or 4-cell stage. Moreover, mRNA expression of three zygotic gene activation-related genes (i.e. Zscan4, Tcstv1 and MuERV-L) was decreased significantly in 2-cell arrested embryos. These results suggest that Rgs2 plays a critical role in early embryo development. PMID: 24524188
    10. RGS2 deficiency decreases uterine artery blood flow by increasing myogenic tone at least partly through prolonged G protein activation PMID: 26811058
    11. Rgs12 has a crucial role in the function of bone-resorbing OCs, particularly in preclinical models of pathological bone loss associated with inflammation-induced bone loss and postmenopausal osteoporosis. PMID: 25909889
    12. RGS2 deficiency impairs renal function and autoregulation by increasing renal vascular resistance and reducing renal blood flow. PMID: 26193676
    13. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. PMID: 25970626
    14. Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. PMID: 26160904
    15. genetic variations and increased inflammatory cytokines can lead to RGS2 repression, which exacerbates AHR and airway remodeling in asthma. PMID: 25368964
    16. RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling. PMID: 25289860
    17. RGS2-deficient VSMC exhibit higher rates of proliferation and coordinate plasticity of Ca(2+)-handling mechanisms in response to PDGF stimulation. PMID: 24846582
    18. Regulator of G protein signaling 2 deficiency accelerates the progression of kidney fibrosis PMID: 24973550
    19. These findins indicate that urotensin II-induced calcium metabolism results in glomerular mesangial cell contraction and suggest that urotensin receptor activation recruts RGS2 to the plasma membrane. PMID: 24105430
    20. This work provides greater insight into the stress proteome and the role of RGS2. PMID: 22922103
    21. Our findings demonstrate a relationship between Rgs2 gene expression level and a propensity for anxious and depressive-like behaviour and reduced social interaction PMID: 22040681
    22. RGS2 knockout caused spontaneous AHR in mice PMID: 22704538
    23. Cardiomyocyte-specific RGS2 overexpression in transgenic mice in vivo did not lead to attenuate ventricular G(q/11)-mediated signaling and hypertrophy in response to pressure overload PMID: 22802950
    24. systemic or endothelium-specific RGS2 deficiency causes endothelial dysfunction resulting in impaired EDHF-dependent vasodilatation. PMID: 22354966
    25. RGS2 negatively regulates TLR2-mediated Nox1 expression via PKC-eta and PLD2 pathway. PMID: 22120521
    26. Data show that Rgs2-deficient mice revealed enhanced bronchoconstriction to spasmogens and an absence of beta(2)-adrenoceptor agonist (LABA)-induced bronchoprotection. PMID: 22080612
    27. These results indicate that Brucella abortus infection induces host RGS2 expression and that up-regulation of [Ca(2+)](i) levels is an essential factor for the intracellular survival of the bacteria within phagocytes. PMID: 22158566
    28. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 PMID: 22057271
    29. These findings not only define RGS2 as a novel negative regulator of the beta(2)AR-G(i) signaling but also provide a potential novel target for the treatment of chronic heart failure. PMID: 21291891
    30. RGS2(-/-) pre-adipocytes had reduced levels of differentiation markers (PPAR gamma; lipoprotein lipase; CCAAT/enhancer binding protein alpha) and also rgs2(-/-) white adipocytes were small relative to controls, suggesting altered adipogenesis. PMID: 21447383
    31. Rgs2 is a critical regulator of the pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment, through regulating MCP-1 production. PMID: 21494556
    32. Data show that reducing RGS2 expression by antisense treatment prevented the increase in GLO1 and GSR1 mRNA and protein expression. PMID: 21510939
    33. Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes. PMID: 20032508
    34. RGS2 is an important cholinergic regulator in the atrium. RGS2(-/-) mice have enhanced susceptibility to atrial fibrillation via enhanced M3 muscarinic receptor activity. PMID: 19966055
    35. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. PMID: 11968023
    36. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts. PMID: 11996904
    37. Both rgs2+/- and rgs2-/- mice exhibited a strong hypertensive phenotype, renovascular abnormalities, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. PMID: 12588882
    38. Rgs2-/- mice develop marked hypertension, and their blood vessels show enhanced contraction and decreased cGMP-mediated relaxation. PMID: 14608379
    39. RGS2 binds directly to the third intracellular (i3) loop of the G(q/11)-coupled M1 muscarinic cholinergic receptor (M1 mAChR; M1i3). PMID: 14976183
    40. cells adapted to deletion of RGS2 by reducing Ca(2+) signaling excitability, achieved by adaptation of all transporters to reduce Ca(2+) influx into the cytosol; thus, IP(3) receptor 1 was down-regulated and IP(3) receptor 3 was up-regulated PMID: 15292238
    41. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. PMID: 15489855
    42. Nitric oxide donor sodium nitroprusside can reduce blood pressure in RGS2 deficient mice. PMID: 15563583
    43. Rgs2 was expressed in undifferentiated pituitary cells, was downregulated at completion of hormone cell differentiation. Pituitary cell differentiation and morphology are normal in Rgs2 mutant mice. PMID: 15661635
    44. The increase in blood pressure in RGS2-/-mice is not solely explained by peripheral vascular mechanisms; a central nervous system mechanism might be implicated by an increased sympathetic tone. PMID: 15661972
    45. Overexpression of Rgs2 in the chondrogenic cell line ATDC5 resulted in accelerated hypertrophic differentiation, thus providing functional validation of microarray data PMID: 16135533
    46. Our data suggest an interaction between RGS2 and the NO-cGMP pathway. The blunted l-NAME response in RGS2(-/-) during the day suggests impaired NO signaling. PMID: 16269576
    47. Results suggest a potential pathophysiological role of loss of fine tuning due to selective RGS2 down-regulation in G(q/11)-mediated remodeling in hypertrophic cardiomyocytes. PMID: 16380388
    48. RGS2 is involved in negative feedback regulation of V2R signaling PMID: 17475820
    49. We found a mismatch between sympathetic nerve traffic and plasma norepinephrine concentrations. This may depend on altered coupling between electrical nerve activity and norepinephrine release or a changed norepinephrine uptake in RGS2-/- mice. PMID: 17507294
    50. group VIA phospholipase A2 (iPLA2beta) plays a pivotal role in Ang II-induced RGS2 mRNA up-regulation in vascular smooth muscle cells PMID: 17613534

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  • 亚细胞定位：
    Cell membrane. Cytoplasm. Nucleus, nucleolus.
  • 组织特异性：
    Expressed in a wide variety of tissues.
  • 数据库链接：

    KEGG: mmu:19735

    STRING: 10090.ENSMUSP00000115558

    UniGene: Mm.28262