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  4. Recombinant Mouse Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial

Recombinant Mouse Receptor tyrosine-protein kinase erbB-2 (Erbb2), partial

  • 货号：
    CSB-YP007763MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007763MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007763MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007763MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007763MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Erbb2; Kiaa3023; NeuReceptor tyrosine-protein kinase erbB-2; EC 2.7.10.1; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; p185erbB2; CD antigen CD340
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
  • 基因功能参考文献：
    1. High HER2 expression is associated with metastasis in breast Cancer. PMID: 29187405
    2. Study shows that within endoplasmic reticulum-related subsurface cistern, sigma-1 receptors, Kv2.1 and neuregulin-1 are clustered in highly specific, non-overlapping, microdomains, whereas ErbB2 and ErbB4 are present in the adjacent presynaptic compartment. This organization may define highly ordered and spatially restricted sites for different signal-transduction pathways. PMID: 28065942
    3. ErbB2 interacts with Nrp1 to form a Sema3d co-receptor expressed by developing coronary endothelium and required for proper connections of the forming coronary veins to the right atrium. PMID: 27356767
    4. The objective of this study was to determine if loss of Stard13 plays a role in mammary tumor progression using transgenic mice expressing the activated ErbB-2 (Neu) oncogene and Cre recombinase (NIC) in mammary epithelium under transcriptional control of the murine mammary tumor virus (MMTV) promoter (MMTV-NIC). PMID: 29218825
    5. Over-expression of HER2 remarkably enhanced the proliferation, invasion and migration of B16 cells. PMID: 28871948
    6. Results indicate the importance of the LDL receptor (LDLR) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C). PMID: 28759039
    7. caErbB2 markedly enhances regeneration of damaged dorsal roots, while evoking little change in intact roots PMID: 28982707
    8. immunocompetent mouse models of HER2/ErbB2-driven breast cancer, CD73 expression by tumor cells and host cells significantly suppressed immune-mediated responses mediated by anti-ErbB2 mAb. PMID: 28855210
    9. We further demonstrate that loss of one allele of PTEN is sufficient to shift isoform dependency from p110alpha to p110beta in vivo. These results provide insight into the molecular mechanism by which ErbB2-positive breast cancer escapes p110alpha inhibition. PMID: 28783168
    10. sought to further echocardiographically characterize the ErbB2(tg) mouse line as a model of hypertrophic obstructive cardiomyopathy PMID: 27538857
    11. investigations revealed that NUMB and NUMBL interacted with small GTPase Rab7 to transition ERBB2 from early to late endosome for degradation. PMID: 28067668
    12. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators. PMID: 27390088
    13. Despite previous evidence suggesting that ErbB receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS pathway in mouse breast cancer model. PMID: 27765041
    14. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis PMID: 26423570
    15. Study showed that suppression of STAT3, STAT5, and STAT6 and overexpression of the proapoptotic factor STAT1, which provides p53-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor overexpression promotes neuronal survival through activation of STAT-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 PMID: 27417725
    16. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity PMID: 26692570
    17. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis. PMID: 26625311
    18. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer. PMID: 26791520
    19. ErbB2 receptor tyrosine kinase in AECs was activated by annexin V, and blockade reduced the fibrotic potential of annexin V-treated AEC-conditioned medium. PMID: 26160872
    20. Disabling of the erbB pathway followed by IFNg modifies phenotype and enhances genotoxic eradication of breast tumors. PMID: 26365188
    21. Ptk6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse. PMID: 26247733
    22. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties. PMID: 26391955
    23. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. PMID: 26254336
    24. These results indicate that OCAM exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB signalling PMID: 25875008
    25. the Krt6a-positive subset of mammary epithelial cells can be induced to form cancer by ErbB2. PMID: 25635772
    26. These results suggested that DS/Cu treatment may be a promising therapy for the prevention of erbB2-positive breast cancer PMID: 25738885
    27. loss of Postn in an ErbB2/Neu/HER2 overexpression model results in apocrine-like tumors that activate an AR-dependent pathway. PMID: 25592291
    28. Inhibition of Erbb2 suppressed the increase in metalloproteinase ADAM12 expression in skin tumors. PMID: 24798404
    29. Data show that Muc4 is upregulated and interacts with erbB2 in gallbladders from BK5.erbB2 mice suggesting its important role during gallbladder carcinogenesis and/or cancer growth by potentiating erbB2 signaling. PMID: 25174601
    30. ERBB2 is both necessary for cardiac myocyte proliferation and sufficient to reactivate postnatal CM proliferative and regenerative potentials. PMID: 25848746
    31. These findings suggest cooperative roles for bile acid and erbB2 activation in epithelial cell proliferation; bile acid appears to accelerate erbB2-induced pro-tumorigenic activities in the biliary tract and skin. PMID: 24839254
    32. A novel function of Erbb2 during atrial conduction system development. PMID: 25269082
    33. Data demonstrate that the E2F transcription factors are integral to HER2+ tumor development and progression. PMID: 24362522
    34. Results support that hyperglycemia may impair NRG1/Erb B2 signaling by disrupting the balance between NRG1 isoforms, decreasing the expression of erbin and correspondingly activating the MAPK pathway PMID: 24252174
    35. ERBB2-positive breast cancers are partially autophagy-deficient even in a wild-type BECN1 background PMID: 24492513
    36. The nuclear ErbB-2 and Stat3 are key players in progestin-induced p21(CIP1) regulation. PMID: 23178160
    37. In the HER2 mouse model, ErbB2 inhibition delays cancer progression, which is associated with HSF1 inactivation and destabilization of HSP90 targets. PMID: 24384723
    38. Wnt pathway-active cell subset in the normal mammary epithelium does not evolve into tumors following ErbB2 activation PMID: 24265712
    39. These results suggest that H. pylori CagA may induce overexpression of the HER-2 protein by increasing HER-2 DNA and mRNA copy number PMID: 24879917
    40. CREB plays an important role in the HER-2/neu-mediated transformation by altering in vitro and in vivo growth characteristics. PMID: 24025972
    41. A novel time-window is identified for embryonic stem cell cardiomyogenesis via Erbb2. PMID: 24364879
    42. Her-2 and beta-catenin appeared co-localized at the cell surface during tumor development and progression. PMID: 23397229
    43. Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis. PMID: 23318421
    44. Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway PMID: 23897819
    45. PIK3CA(H1047R) accelerates HER2-mediated breast epithelial transformation and metastatic progression, alters the intrinsic phenotype of HER2-overexpressing cancers, and generates resistance to approved combinations of anti-HER2 therapies PMID: 23940356
    46. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells. PMID: 23447672
    47. the acquired substrate preference for GAB1 is critical for the ERBB2 mutant-induced oncogenesis. PMID: 23612964
    48. HIF is a major downstream regulator of ERBB2 that protects cells from anoikis and metabolic stress caused by decreased matrix adhesion. PMID: 23585570
    49. HTT protein accelerates breast tumour development and metastasis through ErbB2 signalling. PMID: 23300147
    50. DOCK1-Rac signaling as an HER2 effector pathway essential for HER2-mediated breast cancer progression to metastasis. PMID: 23592719

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Early endosome. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
  • 组织特异性：
    Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers.
  • 数据库链接：

    KEGG: mmu:13866

    STRING: 10090.ENSMUSP00000053897

    UniGene: Mm.290822