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  4. Recombinant Mouse Ras and Rab interactor 1 (Rin1)

Recombinant Mouse Ras and Rab interactor 1 (Rin1)

  • 货号：
    CSB-YP019726MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019726MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019726MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019726MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019726MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rin1; Ras and Rab interactor 1; Ras interaction/interference protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-763
  • 氨基酸序列
    MEDPGETGAH PLGATNLNFV PGHQQKEKPS TDPLYDTPDT RGVQAGGSQQ PARTVSLRER LLITRPVWLQ LRANAAAALH VLRTEPPGTF LVRKSNTRQC QALCVRLPEA SGPSFVSSHY IEESTGGVSL EGSELMFQDL VQLICGYCRT RAIHQAATHK ELEAISHLGM EFWSSSLNTK DQQRPSEAPP IPRLKARSPQ ELDQGTGAAL CFFNPLFPGD LGPTKREKFK RSFKVRVSTE TSSPLSPPAV PPPPVPVLPG TSSSQTERLP PRQLLQRESS VGYRVPGSAA SPCLPPLPSL QEVDCCSPSS SEEEGSSGSP TTSPRLSRPR HRRPLLRSMS SAFCSLLAPE RQVGRAATML MQNRYTAVGQ LVQDLLTQVR AGPEPRELQG IRQALSRARA MLSAELGPEK LLPPERLELV LEKSLHRSVL KPLRPILAAR LRRRLSADGS LGRLAEGFRL ARTQGPGAFG SHLTLSSPVE TEQVRQKLLQ LLRAYSPSAQ VKWLLQACKL LYTALKSQAG ENAGADEFLP LLSLVLAQCD LPDLLLEAEY MSELLEPTLL TGEGGYYLTS LSASLALLSG LSQARALPLS PAQELQRSLA LWEQRRLPAT HSFQHLLRVA YQDPSTGCTS KTLAVPPGSS IATLSQLCAT KFRVTQPDAF GLFLYKDQGY HRLPPEALAH RLPATGYLIY RRAERPETQG AVAEKAKTGS KGPEAGAWEE ETGGLNREGK PRIAVDQEGK DQARGGHIGP EEQKAEGSQA LEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.
  • 基因功能参考文献：
    1. BCR-ABL1 kinase activity is regulated by RIN1 PMID: 21102429
    2. These results provide insight into regulated expression of Rin1, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons. PMID: 19837165
    3. This study provided evidence that Rin1 normally functions as a negative regulator of fear learning and memory (Rin1-/- mice have enhanced fear conditioning and diminished fear extinction). PMID: 19830836
    4. Rin1 links histone ubiquitylation to gene silencing and X inactivation. PMID: 15525528
    5. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. PMID: 15886098
    6. the EphA4 receptor is required for synaptic plasticity in the amygdala, raising the possibility that an underlying mechanism of Rin1 function in amygdala is to down-regulate EphA4 signaling by promoting its endocytosis. PMID: 18723684

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  • 亚细胞定位：
    Cytoplasm. Membrane. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    RIN (Ras interaction/interference) family
  • 组织特异性：
    Highly expressed in brain. Weakly or no expressed in other tissues, except in testis, where it is expressed at intermediate level. In brain, it is mainly expressed in postnatal forebrain neurons in which it is localized in dendrites and colocalizes with R
  • 数据库链接：

    KEGG: mmu:225870

    STRING: 10090.ENSMUSP00000025818

    UniGene: Mm.271922