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  4. Recombinant Mouse Rab effector Noc2 (Rph3al)

Recombinant Mouse Rab effector Noc2 (Rph3al)

  • 中文名称：
    小鼠Rph3al重组蛋白
  • 货号：
    CSB-YP751849MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rph3al重组蛋白
  • 货号：
    CSB-EP751849MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rph3al重组蛋白
  • 货号：
    CSB-EP751849MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rph3al重组蛋白
  • 货号：
    CSB-BP751849MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rph3al重组蛋白
  • 货号：
    CSB-MP751849MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rph3al
  • Uniprot No.：
  • 别名：
    Rph3al; Gm1753; Noc2; Rab effector Noc2; No C2 domains protein; Rabphilin-3A-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-302
  • 氨基酸序列
    MADTIFSSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRSQCLSPG ELEIILQVIQ RAERLDILEQ QRIGRLVERL ETMQRNVMGN GLSQCLLCGE VLGFLGSSSV FCKDCRKKVC TKCGIEASPG QKRPLWLCKI CSEQREVWKR SGAWFYKGLP KYILPLKTPG RADDPHFRPL PVEPTETQPP SAETSRVYTW ARGRVVSSDS DSDSDLSSSS LEDRPLPSGV KGTKGDKPRG DSGASMESPR LGPARPPSHL SGSQSSLGSE AGTGATEPQG GTPAQPEPRV PGKRHTWATP RY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells.
  • 基因功能参考文献：
    1. These results suggest that the dual effector, Noc2, regulates the transition from Rab2a-mediated granule biogenesis to Rab27a-mediated granule exocytosis. PMID: 27927751
    2. In pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca(2+)](i) increases. PMID: 22615885
    3. Results show that Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells. PMID: 15159548
    4. investigated localization of Noc2 immunohistochemically in various endocrine and exocrine tissues in normal mice, including pancreatic islets, the adrenal gland, pituitary gland, salivary gland, and thyroid gland PMID: 16835753
  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle membrane. Note=Recruited to the exocytic secretory vesicles by RAB27A.
  • 组织特异性：
    Highly expressed in pancreatic islets. High to moderate expression in adrenal gland, pituitary gland and ovary.
  • 数据库链接：

    KEGG: mmu:380714

    STRING: 10090.ENSMUSP00000064202

    UniGene: Mm.425697